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Zhou, Zhu


Assistant Professor
Chemistry

Phone:
Office Location:
zzhou1@york.cuny.edu

Education

Degree Institution Field Dates
PhD  University of the Pacific  Pharmaceutical Science   
BS  University of Auckland  Food Science   
BS  China Pharmaceutical University  Pharmacy   
Dr. Zhou’s research focuses on pharmacokinetics/pharmacodynamics. Her research interests include using different experimental techniques, analyzing data from preclinical and clinical, and building models with multiple software packages to predict drug response and disposition. Another research focus is related to drug-drug and herb-drug interactions.

Areas of Expertise

Pharmacokinetics and Pharmacodynamics
Drug-Drug Interactions
Regulatory Science

Articles in Field Of Expertise

Wu L, Kang A, Shan CX, Chai C, Zhou Z, Lin YJ, Bian YY. "LC-Q-TOF/MS-oriented systemic metabolism study of pedunculoside with in vitro and in vivo biotransformation." Journal of Pharmaceutical and Biomedical Analysis. 175(25) 2019: 11276.

Feng SQ, Wang H, Wang Y, Sun RB, Xie Y, Zhou Z, Wang H, Aa J, Zhou F, Wang GJ. "Apatinib induces 3-Hydroxybutyric acid production in the liver of mice by PPARα activation to aid its anti-tumor effect." Cancer Science. 110(10) 2019: 3328-3339.

Wu L, Lin LP, Shan CX, Chai C, Zhou Z, Wu XM, Lu XJ, Liu ZQ, Tan RX.. "LC-MS/MS method development and validation for the determination of ilexsaponin A1 and its application in intestinal bacterial metabolic study. Current Pharmaceutical Analysis." Current Pharmaceutical Analysis. 2019: .

Yu J, Zhou Z, Tay-Sontheimer J, Levy RH, Ragueneau-Majlessi I. "Risk of Clinically Relevant Pharmacokinetic-based Drug-drug Interactions with Drugs Approved by the U.S. Food and Drug Administration Between 2013 and 2016.." Drug Metab Dispos.. 46(6) 2018: 835-845.

Wu L, Tang YP, Shan CX, Chai C , Zhou Z, Shi XQ, Ding N , Wang JY, Tan RX.. "A comprehensive in vitro and in vivo metabolism studies of hydroxysafflor yellow A.." Journal of Mass Spectrometry. 53(2) 2018: 99-108.

Han YY, Ji YW, Kang SY, Dong TY, Zhou Z, Zhang YQ, Chen MJ, Wu W, Tang QQ, Chen T, Wang Y, Xia YK.. "Effects of particulate matter exposure during pregnancy on birth weight: A retrospective cohort study in Suzhou, China." The Science of the Total Environment. 2018: 615: 369-374.

Yu J, Zhou Z, Tay-Sontheimer J, Levy RH, Ragueneau-Majlessi I.. "Intestinal Drug Interactions Mediated by Organic Anion Transporting Polypeptides (OATPs): A Systematic Review of Pre-clinical and Clinical Findings.." J Pharm Sci.. 2017: 106(9):2312-2325.

Yu J, Zhou Z, Owen K, Ritchie TK, Ragueneau-Majlessi I.. "What can be learned from recent NDA/BLA Reviews? A systemic review of drug interaction data for drugs approved by the US FDA in 2015.." Drug Metab Dispos.. 2017: 45(1): 86-108.

Yu J, Ritchie TK, Zhou Z, Ragueneau-Majlessi I.. "Key Findings from Preclinical and Clinical Drug Interaction Studies Presented in New Drug and Biological License Applications Approved by the Food and Drug Administration in 2014.." Drug Metab Dispos.. 2016: 44(1):83-101.

Zhou Z.. "β3-Adrenoceptor as a Novel Treatment Strategy for Depressive Disorders.." Pharm Pharmacol Int J. 1 2014: 21-24.

Ou Y, Geng P, Liao GY, Zhou Z, Wu WT.. "Intracellular GSH and ROS levels may be related to galactose-mediated human lens epithelial cell apoptosis: role of recombinant hirudin variant III." Chemico-biological Interactions. 2009: 179 (2-3): 103.

Refereed Proceedings in Field Of Expertise

Li Y, Park MS, Chan WK, Livesey J, Zhou Z. "Effect of Rutaecarpine on the Benzo(a)pyrene-Induced DNA Damage In Vitro." FASEB Journal. 33:1 2019: .

Zhou Z, Chan P, Uchizono JA. "Modulatory effects of 5-HT2A and AMPA receptors on in vivo serotonin (5-HT) levels in two key areas of the brain related to depression." FASEB Journal. 28:1059.12 2014: .

Zhou Z, Chan P, Sun J, Uchizono JA. "Feedback control of upstream 5-hydroxytryptamine (5-HT) in the dorsal raphe nucleus (DRN) by downstream 5-HT2A and AMPA receptors in the prefrontal cortex." FASEB Journal. 27:1176.1 2013: .

Sun J, Zhou Z, Uchizono JA. "Could the alpha2 heteroreceptor be a target for the relief of depression? An in vivo microdialysis rat study of prazosin, reboxetine, citalopram, and BRL44408.." AAPS Journal. 12(S2):T3476, 2010: .

Presented Papers, Lectures, and Exhibitions and Performances

" Intestinal OATPs mediated drug interactions " 2019: American Society for Clinical Pharmacology and Therapeutics Webinar.

" Effect of Rutaecarpine on the Formation of Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) In Vitro " 2019: Insight Asia-Pacific Research Symposium.

" The Role of PK/PD Modeling & Simulation in Drug Development " 2019: CUNY York College.

" Intestinal Drug Interactions Mediated by Enzymes and Transporters " 2018: China Pharmaceutical University.

" Clinically Significant Intestinal Drug-Drug and Food-Drug interactions " 2017: FDA.

" Identify Possible Clinical Substrates and Inhibitors of Intestinal OATPs: applications of DIDB and ePK gene. Office of Clinical Pharmacology " 2017: FDA.

" Detailed evaluation of PK-based drug-drug interaction data contained in new drug and biologic license applications of drugs approved by the US food and drug administration in 2015 " 2017: American Society for Clinical Pharmacology and Therapeutics.

" Effects of Rutaecarpine on the Pharmacokinetics of Caffeine in Rats " 2017: University of the Pacific.

" Time-dependent induction effect of rutaecarpine on caffeine pharmacokinetics in rats " 2017: Insight Asia-Pacific Research Symposium.

" Examples of Clinically Significant Intestinal Drug-Drug and Food-Drug Interactions " 2016: 19th International Conference on Drug-Drug Interactions.

" What can be learned from recent NDA and BLA Reviews of newly approved drugs? A systemic review of drug interaction data for drugs approved by the US FDA in 2014 " 2015: 20th North American ISSX Meeting.

" Systematic review of the quantitative drug exposure data available in the pharmacogenetic literature using the University of Washington e-PKGene application identifies drugs most sensitive to genetic variations " 2015: 20th North American ISSX Meeting.

" Modulatory effects of 5-HT2A and AMPA receptors on in vivo serotonin (5HT) levels in two key areas of the brain related to depression " 2014: special session. ASPET/EB annual conference.

" Assessment of the effect of 5-HT2A receptors on brain serotonin (5-HT) via a mechanism-based indirect model " 2014: ASCPT.

" Inflammatory Bowel Disease (IBD) database development and meta-analysis on clinically relevant endpoints " 2013: Genentech.

" Exploring the behavior of 5-HT2A and AMPA receptors in modulating serotonin (5-HT) concentrations in the dorsal raphe nucleus " 2013: University of the Pacific.

" Could the alpha2 heteroreceptor be a target for the relief of depression? An in vivo microdialysis rat study of prazosin, reboxetine, citalopram, and BRL44408 " 2010: Pharmaceutical Sciences World Congress (PSWC) conference.

Professional Honors, Prizes, Fellowships

Thomas J. Long Foundation Faculty Fellowship Awards: 2017,2018.

Grants-In-Aid

University of the Pacific, . 2017-2018: $3200.

American College of Clinical Pharmacology, . 2018: $1200.

Offices Held In Professional Societies

Session Co-Chair and Co-Moderator at the 121st American Society for Clinical Pharmacology and Therapeutics Annual Conference: 2020.

Executive Steering Committee of Early Career Communities (ECC), Lead for ECC Webinar Steering Committee in American Society for Clinical Pharmacology and Therapeutics and ECC Representative: 2018-Present.

Session Co-Chair and Moderator for ASCPT Webinar: 2018.

Session Co-Chair and Co-Moderator at the 2018 American College of Clinical Pharmacology Annual Conference: 2018.

Executive Steering Committee of Regulatory Science Communities in American Society for Clinical Pharmacology and Therapeutics: 2017 – Present.

Session Co-chair and Co-Moderator at 19th International Conference on Drug-Drug Interactions: 2016.

Other Professional Activities and Public Service

Meeting Proposal Reviewer for ASCPT Annual Conference: 2019.

Abstract Reviewer for 2019 and 2020 ASCPT Annual Conference: 2018-Present.

Journal Reviewer: Clinical Pharmacology and Therapeutics; The Journal of Clinical Pharmacology; Environmental Pollution: .