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Zhou, Zhu

Assistant Professor

Office Location:


Degree Institution Field Dates
PhD  University of the Pacific  Pharmaceutical Science   
BS  University of Auckland  Food Science   
BS  China Pharmaceutical University  Pharmacy   
Dr. Zhou has a broad background in pharmaceutical science with specific training in pharmacokinetics and expertise in using in vitro, in vivo, and computational approaches to predict and evaluate the disposition of natural products and drugs. Her lab is currently funded by the National Institute of Health. One Postdoc and One PhD student positions are available, please contact Dr. Zhou directly if you are interested in doing research in pharmacokinetics.

Areas of Expertise

Pharmacokinetics and Pharmacodynamics
Drug-Drug Interactions
Regulatory Science

Articles in Field Of Expertise

Zhou Z, Paine MF, Spingdle T, Huang SM, Zhang L. "Cannabis for Medical Use: Clinical Pharmacology Perspectives on Scientific and Regulatory Challenges." Clinical Pharmacology and Therapeutics. 2022: 111(4):732-735.

Estari RK, Chan WK, Dong J, Park MS, Zhou Z. "Effects of Rutaecarpine on the Pharmacokinetics of Caffeine in Rats." Biochemistry and Biophysics Reports. 2021: doi:

Wu L, Kang A, Jin XL, Bao Y, Miao P, Lv T, Zhou Z. "Ilexsaponin A1: In Vitro Metabolites Identification and Evaluation of Inhibitory Drug-Drug Interactions." Drug Metabolism and Pharmacokinetic. 2021: 2;40:100415.

Wu L, Lin LP, Shan CX, Chai C, Zhou Z, Wu XM, Lu XJ, Liu ZQ, Tan RX.. "LC-MS/MS method development and validation for the determination of ilexsaponin A1 and its application in intestinal bacterial metabolic study. Current Pharmaceutical Analysis." Current Pharmaceutical Analysis.. 16(6) 2020: 774 - 781.

Feng SQ, Wang H, Wang Y, Sun RB, Xie Y, Zhou Z, Wang H, Aa J, Zhou F, Wang GJ. "Apatinib induces 3-Hydroxybutyric acid production in the liver of mice by PPARα activation to aid its anti-tumor effect." Cancer Science. 110(10) 2019: 3328-3339.

Wu L, Kang A, Shan CX, Chai C, Zhou Z, Lin YJ, Bian YY. "LC-Q-TOF/MS-oriented systemic metabolism study of pedunculoside with in vitro and in vivo biotransformation." Journal of Pharmaceutical and Biomedical Analysis. 175(25) 2019: 11276.

Ding X, Zhu J, Wang X, Zhou W, Wu K, Zhou Z, Zhou K, Wu D, Jiao J, Xia Y, Wang X. "Different cytotoxicity of disinfection by-product haloacetamides to two exposure pathway-related cell lines: human gastric epithelial cell line GES-1 and immortalized human keratinocyte cell line HaCaT." Science of the Total Environment. 692 2019: 1267-1275.

Mao ZL, Li SS, Zhang L, Yao MM, Zhou Z, Chen MJ. "The mTOR/GCLc/GSH pathway mediates the dose dependent bidirectional regulation of ROS induced by TiO2 NPs in neurogenic cells." Oxidative Medicine and Cellular Longevity. 2019: Article ID 7621561.

Yu J, Zhou Z, Tay-Sontheimer J, Levy RH, Ragueneau-Majlessi I. "Risk of Clinically Relevant Pharmacokinetic-based Drug-drug Interactions with Drugs Approved by the U.S. Food and Drug Administration Between 2013 and 2016.." Drug Metab Dispos.. 46(6) 2018: 835-845.

Huang ZY, Xu B, Huang XM, Zhang YQ, Yu MM, Han XM, Zhang Y, Song L, Xia YK, Zhou Z, Wang XR, Chen MJ, Lu CC.. "Metabolomics reveals the role of Acetyl-L-carnitine metabolism in γ-Fe2O3 NP-induced embryonic development toxicity via mitochondria damage." Nanotoxicology.. 13(2) 2019: 204-220.

Wu L, Tang YP, Shan CX, Chai C , Zhou Z, Shi XQ, Ding N , Wang JY, Tan RX.. "A comprehensive in vitro and in vivo metabolism studies of hydroxysafflor yellow A.." Journal of Mass Spectrometry. 53(2) 2018: 99-108.

Han YY, Ji YW, Kang SY, Dong TY, Zhou Z, Zhang YQ, Chen MJ, Wu W, Tang QQ, Chen T, Wang Y, Xia YK.. "Effects of particulate matter exposure during pregnancy on birth weight: A retrospective cohort study in Suzhou, China." The Science of the Total Environment. 2018: 615: 369-374.

Yu J, Zhou Z, Tay-Sontheimer J, Levy RH, Ragueneau-Majlessi I.. "Intestinal Drug Interactions Mediated by Organic Anion Transporting Polypeptides (OATPs): A Systematic Review of Pre-clinical and Clinical Findings.." J Pharm Sci.. 2017: 106(9):2312-2325.

Yu J, Zhou Z, Owen K, Ritchie TK, Ragueneau-Majlessi I.. "What can be learned from recent NDA/BLA Reviews? A systemic review of drug interaction data for drugs approved by the US FDA in 2015.." Drug Metab Dispos.. 2017: 45(1): 86-108.

Yu J, Ritchie TK, Zhou Z, Ragueneau-Majlessi I.. "Key Findings from Preclinical and Clinical Drug Interaction Studies Presented in New Drug and Biological License Applications Approved by the Food and Drug Administration in 2014.." Drug Metab Dispos.. 2016: 44(1):83-101.

Refereed Proceedings in Field Of Expertise

Zhou Z, Yang XN, Li Y, Zhou NT, Zhang L,Huang SM, Madabushi R, Ramanmoorthy A. Grapefruit juice drug interactions: where are we? Clinical Pharmacology&Therapetuics 2021; 109 S1:S22. "." . : .

Li Y, Park MS, Chan WK, Livesey J, Zhou Z. "Effect of Rutaecarpine on the Benzo(a)pyrene-Induced DNA Damage In Vitro." FASEB Journal. 33:1 2019: .

Presented Papers, Lectures, and Exhibitions and Performances

" Drug-Drug Interactions in Those 65+: Are They Getting the Right Dose? " 2022: ACCP Annual Meeting.

" New Age Elderly: Are We Prepared for the Future of Aging? " 2022: ASCPT Annual Meeting.

" Grapefruit Juice Drug Interactions: Where are we? " 2022: FDA.

" Transporter and Enzyme Mediated Intestinal Drug and Food-drug interactions " 2021: St John's University.

" Intestinal OATPs mediated drug interactions " 2019: American Society for Clinical Pharmacology and Therapeutics Webinar.

" Effect of Rutaecarpine on the Formation of Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) In Vitro " 2019: Insight Asia-Pacific Research Symposium.

" Intestinal Drug Interactions Mediated by Enzymes and Transporters " 2018: China Pharmaceutical University.

" Clinically Significant Intestinal Drug-Drug and Food-Drug interactions " 2017: FDA.

" Identify Possible Clinical Substrates and Inhibitors of Intestinal OATPs: applications of DIDB and ePK gene. Office of Clinical Pharmacology " 2017: FDA.

" Detailed evaluation of PK-based drug-drug interaction data contained in new drug and biologic license applications of drugs approved by the US food and drug administration in 2015 " 2017: American Society for Clinical Pharmacology and Therapeutics.

" Time-dependent induction effect of rutaecarpine on caffeine pharmacokinetics in rats " 2017: Insight Asia-Pacific Research Symposium.

" Examples of Clinically Significant Intestinal Drug-Drug and Food-Drug Interactions " 2016: 19th International Conference on Drug-Drug Interactions.

Professional Honors, Prizes, Fellowships

2023 ASCPT Darrell Abernethy Early Stage Investigator Award: 2023.

2022 National Institute on Aging (NIA) Butler-Williams Scholar Program: 2022.

ASCPT Member of the Month (featured in the May issue of Clinical Pharmacology & Therapeutics): 2022.

Stewart Travel Award: 2020.

Thomas J. Long Foundation Faculty Fellowship Awards: 2017,2018.


NIH, . 2022-2026: .

ASCPT, . 2023: .

PSC-CUNY, . 2022-2023: .

PSC-CUNY, . 2020-2021: .

Faculty Fellowship Publication Program, City University of New York, . 2021: .

University of the Pacific, . 2017-2018: .

Offices Held In Professional Societies

Chair for Regulatory Science Community in American Society for Clinical Pharmacology and Therapeutics (ASCPT): 2022-2023.

Diversity, equity, and inclusion (DEI) leader for ASCPT in National Science Foundation (NSF) funded- ACCESS+ program: 2022.

Vice President for Education, American Chinese Pharmaceutical Association: 2021-Present.

Vice-Chair for Regulatory Science Community in ASCPT: 2021-2022.

Other Professional Activities and Public Service

NIH Panel Reviewer (Ad hoc reviewer), DMPB study section: 2023.

Special Issue Guest Editor: Pharmaceutics: 2022-2023.

NIH Early Career Reviewer (ECR) Program: 2022-.

Journal Reviewer: Clinical Pharmacology and Therapeutics; Drug Metabolism and Disposition; Clinical & Translational Science; The Journal of Clinical Pharmacology; PLOS One; Journal of Pharmaceutical and Biomedical Analysis; Environmental Pollution; Science of the Total Environment; Pharmacy & Pharmacology International Journal: .

Junior Science and Humanities Symposium Judge: 2021,2022.

Book (“Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications”) Chapter Reviewer: 2020.

2020 American Conference on Pharmacometrics Abstract Reviewer: 2020.

New York State Contact Tracer Initiative Interviewer: 2020.

Meeting Proposal and Abstract Reviewer for ASCPT Annual Conference: 2018-Present.