Lee, Jong-Ill
 

Lee, Jong-Ill


Associate Professor
Chemistry

Phone: 718-262-2665
Office Location: AC-3F01G
jilee@york.cuny.edu
http://web.york.cuny.edu/~jilee

Office Hours  
Thursday Office Hour  12-2 PM 
MW Organic Workshop  11 AM - 1 PM 

Education

Degree Institution Field Dates
PhD  Michigan State University  Organic Chemistry  2001 
BS  Pusan National University  Chemistry  1989 

Numerous current therapeutic agents are reported to accompany severe side effects that degrade the usefulness of chemotherapeutic agents and limit treatment options. The inefficiency of a therapeutic drug originated from the lack of selective targeting to a specific place. Therefore, the development of controlled drug delivery devices possessing spatiotemporal resolution and targeting ability is a crucial feature.

However, these small phototriggers are mostly activated by harmful UV light. Thus, it is solicited to develop a phototrigger that works by light in the red or infrared range of the spectrum. Recently, the construction and development of photochemically activated dendritic drug delivery devices with high efficiency and without harmful UV usage have been accomplished in our laboratory.

Photoactive drug carrier

Areas of Expertise

Organic Photochemistry
Physical Organic Chemistry
Drug Delivery

Articles in Field Of Expertise

Jong I. Lee. "Bis-1,2-(4-acetylphenylethynyl)-4,5-dimethoxybenzene as a drug release device via two-photon activation by Near IR." Tetrahedron Letters. 2019 (in preparation): .

Jong I. Lee; Mani Bushan; Galen Loving; Chi Zhang; Richard Givens. "A novel separation methodology using tight-binding photolabile cryptands." . 2018 (in preparation): .

Jong I. Lee; Jeonghee Kang. "Role of Singlet πσ* State on Benzene Rings to Photophysical Properties of fluorinated benzenes and Pentafluorophenylalanine." . 2018 (in preparation): .

Nia Rene; Kisha Ali; Jeonghee Kang; Jong I. Lee. "Synthesis of first generation dendron, GABA caged bis-1,2-(4-acetylphenylethynyl)-4,5-dimethoxybenzene for photorelease study." Letter in Organic Chemistry. 2018 (submitted): .

Pratikkumar Rathod; Manjeet Kaur; Hsin-Pin Ho; Marissa E. Louis; Basant Dhital; Philip Durlik; Gregory Boutis; Kevin J. Mark; Jong I. Lee; Emmanuel J. Chang. "Qualification of desmosine and isodesmosine using MALDI-ion trap tandem mass spectrometry." Analytical and Bioanalytical Chemistry. 410(3) 2018: 1-9.

Sukjin Jang; Azhad Chowdhury; Jeonghee Kang; Jong I. Lee. "Study of mechanism in photorelease reaction of GABA from 1,2,2-triphenylethanone (TPE)." Letter in Organic Chemistry. 11(3) 2014: 230-235.

Richard S. Givens; Dominik Heger; Bruno Hellrung; Yavor Kamdzhilov; Marek Mac; Peter G. Conrad II;Elizabeth Cope; Jong I. Lee; Julio F. Mata-Segreda; Richard L. Showen; Jakob Wirz;. "The Photo-Favorskii Reaction of p-Hydroxyphenacyl Compounds Is Initiated by Water-Assisted, Adiabatic Extrusion of a Triplet Biradical.." J. Am. Chem Soc.. 130(11) 2008: 3307-3309..

Mansour M. Hassan; Chi Zhang; Jong-ill Lee; K. Mani Bushan; Anne McCasland; Richard S. Givens; Daryle H. Busch;. "Dynamics of Switch-Binding by a Linear Ligand that Transforms to a Macrocycle upon Chelation to a Metal Ion: Synthesis, Kinetics, and Equilibria." ACS Symposium Series 943, Paul Wang and Tiffany Zachry, (eds.). Ch. 11 2006: 186-222.

Richard S. Givens; Mani B. Kotala; Jong-Ill Lee;. "Mechanistic overview of phototriggers and cage release." Ch 2 in “Dynamic Studies in Biology” Maurice Goeldner and Richard S. Givens, (eds.). 2005: 95-129.

Richard S. Givens; Abraham Yousef; Jong-Ill Lee;. "Photoprotecting Groups." CRC Handbook of Organic Photochemistry and Photobiology, W. Horspool and F. Lenci, (eds.). 69, 2004: 1-45.

Richard S. Givens; Jong-Ill Lee;. "The p-Hydroxyphenacyl Photoremovable Protecting Group." Journal of Photoscience. 10(1) 2003: 37-48.

Peter J. Wagner; Jong-Ill Lee;. "Dipole mediated regioselectivity in [2+2] photocycloadditions to triplet benzenes." Tetrahedron Letter. 43 2002: 3569-3571.

Dai, Jinhua; Anagi M. Blachandra; Lee, Jong Il; Bruening, Merlin L.;. "Controlling ion transport through layered polyelectrolyte membranes by derivatization with photolabile functional groups." Macromolecules. 35 2002: 3164-3170.

Chapters in Field Of Expertise

Mansour M. Hassan; Chi Zhang; Jong I. Lee;K. Mani Bushan; Anne McCasland; Richard S. Givens; Daryle H. Busch. "Dynamics of Switch-Binding by a Linear Ligand that Transforms to a Macrocycle upon Chelation to a Metal Ion: Synthesis, Kinetics, and Equilibria." ACS Symposium Series 943, Paul Wang and Tiffany Zachry (eds.). Ch. 11 2006: 186-222.

Richard S. Givens, Mani B. Kotala, Jong I. Lee. "Mechanistic overview of phototriggers and cage release." Dynamic Studies in Biology, Maurice Goeldner and Richard S. Givens (eds.). Ch. 2 2005: 95-129.

Presented Papers, Lectures, and Exhibitions and Performances

" Jong I. Lee: "Design and Development of Novel Phototriggers for Drug Delivery" " October 9, 2018: Queens High School for the Sciences at York College Science Research Class.

" Jong I. Lee: "Photochemical release of glycine from excited state dendrimer: An example of novel drug delivery" " August 19-23, 2018: ACS National Meeting at Boston, MA.

" Kelly Valladolid, Yael Muladjanoy, Jong I. Lee: "Computational Study of first generation Dendron in excited triplet state" " May 5, 2018: 66th Undergraduate Research Symposium of ACS New York Section.

" Andre Barrella, Marium Akhtar, Jong I. Lee: "Synthesis and photorelease study of glycine caged bis-1,2-(4-acetylphenylethynyl)-4,5-dimethoxybenzene, first generation dendron phototrigger" " June 9-12, 2016: 2016 Middle Atlantic Regional Meeting at Riverdale, NY.

" Nia Rene, Jong I. Lee: "Synthesis and Photoreaction of 1st Generation Dendrimer Potential Drug Delivery Device" " May 9, 2015: 63rd Undergraduate Research Symposium of ACS New York Section.

" Jong I. Lee: "Development of a phototrigger for efficient Drug Delivery" " September 4, 2013: St. Joseph's College at Brooklyn Department of Natural Science.

" Carmen Lorenzo, Pamela Djan, Jong I. Lee, Jeonghee Kang: "Spectroscopic Study of Metal Complexed Anthocyanins from Plants for Dye-Sensitized Solar Cells" " June 1, 2012: Middle Atlantic Regional Meetings of the American Chemical Society.

" Anthony Pagan Jong I. Lee, Jeonghee Kang: "Synthesis and Characteristic Study of Artificial Anthocyanidine" " June 1, 2012: Middle Atlantic Regional Meetings of the American Chemical Society.

" Pamela Djan, Carmen Lorenzo, Anthony Pagan, Jong I. Lee, Jeonghee Kang: "Study of the pH Dependent Anthocyanin Structures for Dye-Sensitized Solar Cells" " May 5, 2012: Undergraduate Research Symposium of ACS New York Section.

" Carmen Lorenzo, Anthony Pagan, Pamela Djan, Jong I. Lee, Jeonghee Kang: "Spectroscopic Study of Metal Complexed Anthocyanins from Berries for Dye-Sensitized Solar Cells" " May 5, 2012: Undergraduate Research Symposium of ACS New York Section.

" Anthony Pagan, Jong I. Lee, Jeonghee Kang: "Synthesis and Characteristic Study of Artificial Anthocyanidine" " May 2, 2012: Undergraduate Research Symposium of ACS New York Section.

" Jong I. Lee: "Synthesis and Development of New Phototrigger: 1,1,2-Triphenyl Ethanone Group" " 2011: Undergraduate Research Section of ACS Local Meeting.

" Dex-Ann Brown, Adam A. Profit, Ruel Z. B. Desamero, Jong I. Lee, Jeonghee Kang: "Probing the mechanism behind the inhibition of Src Kinase" " 2009: Undergraduate Research Section of the ACS Local Meeting.

" Jeonghee Kang, Adam A. Profit, Jong I. Lee, Ruel Z. B. Desamero: "Optical Study of Src Inhibitors" " 2008: CUNY Graduate Center.

" Jong I. Lee, Kisha Ali, Azhad Chowdary: "Synthesis and Photolysis of Phenylethynyl Dendron” " April 28, 2008: ACS Local Meeting at Queens, NY.

" Jong I. Lee, Asnan Riamoni, Sujit Roy: "Synthesis and Photolysis of Dendron Based Phototrigger: Phenylacetylenyl phenacyl dendron" " August 2007: ACS National Meeting at Boston, MA.

" Chicheng Ma, Jong I. Lee, George Orosz, Richard S. Givens: "4-Hydroxyphenacyl as a Phototrigger for Tyrosine and Other Phenols: At a Crossroad" " October 25-27, 2006: 41st Midwest Regional Meeting of the ACS at Quincy, IL.

" Jong I. Lee: "Photoremovable Protecting Groups in Biology and Chemistry" " October 18, 2005: LIU-Brooklyn Chemistry Department Colloquium Speaker.

" Jong I. Lee: "Phototriggers and Cage Release" " April 11, 2005: CUNY Queens College Chemistry Department Colloquium Speaker.

" Richard S. Givens, Daryle H. Busch, Chi Zhang, Jong I. Lee, Mani K. Bushan, Galen Loving: "Capture and release: Managing tight-binding receptors" " August 22-26, 2004: ACS National Meeting at Philadelphia, PA.

" Jong I. Lee: "Phototriggers in Biology and Chemistry" " April 2, 2004: Stephen F. Austin State University Chemistry Department Colloquium Speaker.

" Daryle Busche, Richard S. Givens, Xiaobin Zuo, Chi Zhang, Donnati Mosha, Jong I. Lee, Mani K. Bushan, Abdoulhaeed Mansour Hassan, Galen Loving: "Exploiting Ultra Tight-binding Ligands for Separation Technologies" " September 7-11, 2003: ACS National Meeting at New York, NY.

" Jong I. Lee, Richard S. Givens: "The Photoactivation of Amino Acid and Peptide Side Chains: New Applications of the pHP Phototrigger" " October 2002: ACS Regional Meeting at Lawrence, KS.

" Jong I. Lee, Chi Zhang, Richard S. Givens, Daryle H. Busch: "Managing Tight Binding Receptors for New Separations Technologies: New Applications of the photolabile polyether cryptand" " October 2002: ACS Regional Meeting at Lawrence, KS.

" Abdoulhameed Mansour Hassan, Chi Zhang, Richard S. Givens, Jong I. Lee, Daryle H. Busch: "Kinetics of Reaction of Nickel(II) with a Linear Polydentate Ligand Capable of Forming a Macrocycle" " October 2002: ACS Regional Meeting at Lawrence, KS.

" Galen S. Loving, Chi Zhang, Jong I. Lee, Richard S. Givens Daryle H. Busch: "A New Approach to the Capture and Photorelease of Metal Ions: A Clutching Macrocycle" " October 2002: ACS Regional Undergraduate Session at Lawrence, KS.

" Jinhua Dai, Jong I. Lee, Merlin L. Bruening: "Controlling ion transport through layered polyelectrolyte membranes by derivatization with photolabile functional groups" " August 2001: ACS National Meeting at Chicago, IL.

" Ronald M. Scott, Stephen E. Schullery, Nahid Hemati, Jong I. Lee: "Determination of Hydrogen-binding Equilibrium Constants and Stoichiometries in Short-Range Solvation by Halogenated Alcohols" " April 2, 1995: Abstracts of Papers of the American Chemical Society.

" Jong I. Lee, Jeonghee Kang, S. J. Choi: "Isolation and Purification of Pigments of Lactuca Scariola L and (o-, m-, p-) Nitroanilines by Modified TLC" " 1987: Conference for Research Paper Contest by College of Natural Science at PNU.

Grants-In-Aid

PSC-CUNY Research Award, Drug Release from Conjugated Dendron through Multi-Photon Absorption (Submitted). 2018-2019: $5,500.

PSC-CUNY (TRADA-44-699), A Green Method for Selective Protection for Amine and Alcohol. 2013-2014: $3,000.

PSCREG-38-1089, Asymmetric Addition of Fluorine using Fluorinated Coenzym Analogs. 2007-2008: $3,106.

PSC-CUNY, Photochemically Controlled Drug Delivery Nanodevices. 2005-2006: $4,040.

CUNY Equipment Grant, Probing the dynamics of binding and catalysis in dihydropteridine reductase using a mT-jump stopped-flow device. 2006: $40,000.

Other Professional Activities and Public Service

JSHS Judge: 2010-2018 (chair since 2011).

NYCSEF Judge: 2011-2014- 2017.

Chair of Science Division of KMSO Science Fair: 2010-2014.

WAC Lighting Foundation Invitational Science Fair: 2013-2014.

STEM Expo: 2012-2017.

KMSO Poster Session Judge: 2009-2015.

Mathematical Science Exposition for High School Students Judge: 2008.

Freeport High School Science Fair Judge: 2007.

Member of Inter-American Photochemical Society: 2009-present.

Member of the American Chemical Society: 2000-present.

Reviewer for International Journal of Chemistry: 2012-present.