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Levinger, Louis

Overview

Curriculum Vitae

  1. Education


    Degree Institution Field Dates
    PhD  University of North Carolina, Chapel Hill  Biochemistry  1978 
    BS  Antioch College  Biology  1973 

  2. Full-Time Academic Experience


    Institution Rank Field Dates
    University of Delaware  Professor  Natural Sciences/  2002-2012 
    York College/CUNY  Associate Professor  Natural Sciences/Biology  1997-2002 
    York College/CUNY  Assistant Professor  Natural Sciences/Biology  1992-1997 
    York College/CUNY  Research Associate Professor  Natural Sciences/Biology  1990-1992 

  3. Part-Time Academic Experience


  4. Non Academic Experience


  5. Employment Record At This Institution

    Rank Dates
    Professor of Biology  July 2007 
    Professor of Natural Sciences  2004 

  6. Publications In Field Of Expertise

    1. Books:
    2. Papers in Professional Journals:
      1. Articles:

        Levinger L, O Jacobs*, M James*.. "In vitro 3' end endonucleolytic processing defect in a human mitochondrial tRNASer(UCN) precursor with the U7445C substitution, which causes non-syndromic deafness." Nucleic Acids Research. 29 2001: 4334-4340.

        Levinger, L., Giegé, R., Florentz, C. "Pathology-related substitutions in human mitochondrial tRNAIle reduce precursor 3' end processing efficiency in vitro." Nucleic Acids Research. 31 2003: 1904-1912.

        Dubrovsky, E.B., Dubrovskaya, V.A., Levinger, L., Schiffer, S., Marchfelder, A.. "The biological role of RNase Z is tRNA 3’ end processing of mitochondrial and nuclear pre-tRNAs." Nucleic Acids Research. 32 2004: 255-262.

        Levinger, L., Oestreich, I., Florentz, C., Mörl, M. "A pathogenesis-associated mutation in human mitochondrial tRNALeu(UUR) leads to reduced 3’-end processing and CCA addition." J. Mol. Biol.. 337 2004: 535-544.

        Toompuu, M., Levinger, L., Nadal, A., Jacobs, H.. "The 7472insC mtDNA mutation impairs 5´ and 3´ processing of tRNASer(UCN)." Biochem. Biophys. Res. Comm.. 322 2004: 803-813.

        Levinger L, Mörl M, Florentz C.. "Mitochondrial tRNA 3' end metabolism and human disease." Nucl. Acids Res.. 32 2004: 5430-5441.

        Zareen, N., Yan, H., Hopkinson, A.*, Levinger, L.. "Residues in the conserved His domain of fruit fly tRNase Z that function in catalysis are not involved in substrate recognition or binding." J. Mol. Biol.. 350 2005: 189-199.

        Yan, H., Zareen, N., and Levinger, L.. "Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the tRNase Z cleavage site, processing kinetics and substrate secondary structure." J. Biol. Chem.. 281 2006: 3926-3935.

        Zareen, N., Hopkinson, A.*, Levinger, L.. "Residues in two homology blocks on the amino side of the tRNase Z His domain contribute unexpectedly to pre-tRNA 3’ end processing." RNA. 12 2006: 1104-1115.

        Karkashon, S., Hopkinson, A, and Levinger, L.. "tRNase Z Catalysis and Conserved Residues on the Carboxy Side of the His Cluster." Biochemistry. 46 2007: 9380-9387.

        Hopkinson, A., and Levinger, L.. "Effects of Conserved D/T Loop Substitutions in the Pre-tRNA Substrate on tRNase Z Catalysis." RNA Biol.. 5 2008: 104-111.

        Levinger, L., Hopkinson, A., Desetty, R., and Wilson, C.. "Effect of changes in the flexible arm on tRNase Z processing kinetics." J. Biol. Chem.. 284 2009: 15685-15691.

        Schaller A, Desetty R, Hahn D, Jackson CB, Nuoffer JM, Gallati S, Levinger L.. "Impairment of mitochondrial tRNA(Ile) processing by a novel mutation associated with chronic progressive external ophthalmoplegia." Mitochondrion. 11 2011: 488–496.

        Levinger, L., and Serjanov, D.. "Pathogenesis-related Mutations in the T-Loops of Human Mitochondrial tRNAs Affect 3’ End Processing and tRNA Structure." RNA Biol.. in press 12-13-2011 2012: 12.

        Christopher Wilson, Daryl Ramai, Dmitri Serjanov, Neema Lama, Louis Levinger and Emmanuel J. Chang. "A Flexible Arm and Tether in the Long Form of tRNase Z Characterized by Limited Proteolysis and Mass Spectrometry." J. Biol. Chem.. submitted 02-10-2012 2012: 13.

      2. Proceedings:
        1. Refereed Proceedings
        2. Non-Refereed Proceedings
    3. Chapters in Books:
    4. Government Reports or Monographs
    5. Book Reviews:

  7. Other Publications

    1. Books:
    2. Papers in Professional Journals:
      1. Articles:
      2. Proceedings:
        1. Refereed Proceedings
        2. Non-Refereed Proceedings
    3. Chapters in Books:
    4. Government Reports or Monographs
    5. Book Reviews:

  8. Presented Papers, Lectures, And Exhibitions And Performances

  9. Patents

    None

  10. Work In Progress

    1. Books in progress:
    2. Papers in Progress:
    3. Papers submitted to journals for consideration:
    4. Research in progress:

  11. Professional Honors, Prizes, Fellowships

    Sabbatical Fellowship: 2001-2002.

  12. Grants-In-Aid

    NIH F33GM103190-01, Domain Structure of tRNase ZL, the Long Form of tRNase Z. submitted fellowship proposal: .

    9R15GM101620-03, tRNase Z is Central to Pre-tRNA Maturation. 7/1/12-6/30/15 pending with a priority of 10: $300,000.

    NIH SC3GM08153, The Head of the tRNase Z Recognition and Binding Domain. 7/1/08-6/30/12: $300,000.

    NIH SC3GM08153S1, The Head of the tRNase Z Recognition and Binding Domain. Supplemental support for a research technician. 7/1/08-5/31/11: $77,750.

    NIH 2R15CA120072-02, Regulation of Substrate Binding and Catalysis in tRNase Z. 7/1/09-6/30/12: $150,000.

    NIH 2R15CA120072-02S1, Supplemental summer support for undergraduates. 7/1/09-6/30/11: $35,121.

    NIH 2R15CA120072-02S1, Undergraduate Diversity supplement - Kyla-Gaye Pinnock. 10/01/09-5/31/12: $42,842.

    Reso A Equipment, Purchase of an AKTA Purifier FPLC. 12/20/2010: $91,000.

    NIH T34GM08498, Laboratory Research Training for Minority Undergraduates. 6/1/06-5/31/08: $100,000.

  13. Institutional Service

    1. Service to the Department
    2. Service to the School
    3. Service to the College
    4. Service to the Graduate Center
    5. Service to the University

  14. Offices Held In Professional Societies

  15. Other Professional Activities And Public Service

  16. Teaching Activities At This Institution

    1. Courses Taught (List)
      Course Description
      Bio 120  Principles of Inheritance and Human Reproduction 
      Bio 202  Biological Principles II 
      Btec 203  Introduction to Biotechnology 
      Bio 343  Laboratory Exercises in Genetics 
      Bio 344  Molecular and General Genetics 
      Bio 412  Biochemistry 
      Btec 480  Theory and Experimentation in Biotechnology 
    2. New courses/programs developed (list):