Fay, Francois

Fay, Francois

Curriculum Vitae

Asst Professor

Phone: 718-262-5255
Office Location:

Office Hours  
Tuesday, Thursday  4pm - 5pm 


Degree Institution Field Dates
PhD  Queen’s University Belfast  Pharmacy  2010 
MS  University of Bordeaux  Biotechnology  2006 
My goal is to establish at York College a laboratory in the field of bio-inspired nanotechnology for the diagnostic and the treatment of local inflammation in diseases such as atherosclerosis, sepsis, rheumatoid arthritis, and cancers.

Areas of Expertise

Drug Delivery System, Nanomedicine, Molecular Imaging
Formulation scale-up
Interaction material/biological system
Cell biology

Books in Field Of Expertise

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Articles in Field Of Expertise

Fay F, Hansen L, Hectors SJCG, Sanchez-Gaytan BL, Zhao Y, Tang J, Munitz J, Alaarg A, Braza MS, Gianella A, Aaronson SA, Reiner T, Kjems J, Langer R, Hoeben FJM, Janssen HM, Calcagno C, Strijkers GJ, Fayad ZA, Pérez-Medina C, Mulder WJM.. "Investigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal ImaginInvestigating the Cellular Specificity in Tumors of a Surface-Converting Nanoparticle by Multimodal Imaging.g.." Bioconjugate Chemistry. 2017: .

Sanchez-Gaytan BL, Fay F, Hak S, Alaarg A, Fayad ZA, Pérez-Medina C, Mulder WJ, Zhao Y.. "Real-Time Monitoring of Nanoparticle Formation by FRET Imaging." Angew Chem Int Ed Engl. 2017: .

Alaarg A, Senders ML, Varela-Moreira A, Pérez-Medina C, Zhao Y, Tang J, Fay F, Reiner T, Fayad ZA, Hennink WE, Metselaar JM, Mulder WJM, Storm G.. "A systematic comparison of clinically viable nanomedicines targeting HMG-CoA reductase in inflammatory atherosclerosis.." J Control Release. 2017: .

Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M.. "Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.." Nature Communications. 2017: .

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E.. "Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis.." ACS Nano. 2017: .

Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ.. "Immune cell screening of a nanoparticle library improves atherosclerosis therapy.." Proceedings of the National Academy of Sciences. 2016: .

Ramos-Cabrer P, Fay F, Sanchez-Gaytan BL, Tang J, Castillo J, Fayad ZA, Mulder WJ.. "Conformational Changes in High-Density Lipoprotein Nanoparticles Induced by High Payloads of Paramagnetic Lipids.." ACS Omega. 2016: .

Zhao Y, Fay F, Hak S, Manuel Perez-Aguilar J, Sanchez-Gaytan BL, Goode B, Duivenvoorden R, de Lange Davies C, Bjørkøy A, Weinstein H, Fayad ZA, Pérez-Medina C, Mulder WJ.. "Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy.." Nature Communications. 2016: .

Spence S, Greene MK, Fay F, Hams E, Saunders SP, Hamid U, Fitzgerald M, Beck J, Bains BK, Smyth P, Themistou E, Small DM, Schmid D, O'Kane CM, Fitzgerald DC, Abdelghany SM, Johnston JA, Fallon PG, Burrows JF, McAuley DF, Kissenpfennig A, Scott CJ.. "al Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation." Science Translational Medicine. 2015: .

Sanchez-Gaytan B*, Fay F*, Lobatto M*, Tang J, Ouimet M, Kim Y, van der Staay S, van Rijs S, Priem B, Zhang L, Fisher E, Moore K, Langer R, Fayad Z, Mulder WJ.. "HDL-mimetic PLGA nanoparticle for the targeting of atherosclerosis plaque macrophages.." Bioconjugate Chemistry. 2015: .

Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ.. "Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation." Science Advances. 2015: .

Lobatto M, Calcagno C, Millon A, Senders M, Fay F, Robson P, Ramachandran S, Binderup T, Paridaans M, Sensarn, S, Rogalla S, Gordon R, Cardoso L, Storm G, Metselaar J, Contag C, Stroes E, Fayad Z, Mulder WJ.. "Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging.." ACS Nano. 2015: .

Schmid D, Fay F, Small DM, Jaworski J, Riley JS, Tegazzini D, Fenning C, Jones DS, Johnston PG, Longley DB, Scott CJ.. "Efficient drug delivery and induction of apoptosis in colorectal tumors using a death receptor 5-targeted nanomedicine.." Molecular Therapy. 2014: .

Schmid D, Jarvis GE, Fay F, Small DM, Greene MK, Majkut J, Spence S, McLaughlin KM, McCloskey KD, Johnston PG, Kissenpfennig A, Longley DB, Scott CJ.. "Nanoencapsulation of ABT-737 and camptothecin enhances their clinical potential through synergistic antitumor effects and reduction of systemic toxicity.." Cell Death & Disease. 2014: .

Kim Y, Lobatto ME, Kawahara T, Lee Chung B, Mieszawska AJ, Sanchez-Gaytan BL, Fay F, Senders ML, Calcagno C, Becraft J, Tun Saung M, Gordon RE, Stroes ES, Ma M, Farokhzad OC, Fayad ZA, Mulder WJ, Langer R.. "Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis.." Proceedings of the National Academy of Sciences. 2014: .

Zhao Y, van Rooy I, Hak S, Fay F, Tang J, Davies Cde L, Skobe M, Fisher EA, Radu A, Fayad ZA, de Mello Donegá C, Meijerink A, Mulder WJ.. "Near-infrared flurescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice.." ACS Nano. 2013: .

Allijn IE, Leong W, Tang J, Gianella A, Mieszawska AJ, Fay F, Ma G, Russell S, Callo CB, Gordon RE, Korkmaz E, Post JA, Zhao Y, Gerritsen HC, Thran A, Proksa R, Daerr H, Storm G, Fuster V, Fisher EA, Fayad ZA, Mulder WJ, Cormode DP.. "Gold nanocrystal labeling allows low-density lipoprotein imaging from the subcellular to macroscopic level.." ACS Nano. 2013: .

Kim Y*, Fay F*, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy EJ, Ma M, Moore K, Farokhzad OC, Fisher EA, Mulder WJ, Langer R, Fayad ZA.. "Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics.." ACS Nano. 2013: .

Zaric M, Lyubomska O, Touzelet O, Poux C, Al-Zahrani S, Fay F, Wallace L, Terhorst D, Malissen B, Henri S, Power UF, Scott CJ, Donnelly RF, Kissenpfennig A.. "Skin dendritic cell targeting via microneedle arrays laden with antigen-encapsulated poly-D,L-lactide-co-glycolide nanoparticles induces efficient antitumor and antiviral immune responses.." ACS Nano. 2013: .

Fay F, Sanchez-Gaytan BL, Cormode DP, Skajaa T, Fisher EA, Fayad ZA, Mulder WJ.. "Nanocrystal Core Lipoprotein Biomimetics for Imaging of Lipoproteins and Associated Disease.." Current Cardiovascular Imaging Reports. 2013: .

Abdelghany SM, Schmid D, Deacon J, Jaworski J, Fay F, McLaughlin KM, Gormley JA, Burrows JF, Longley DB, Donnelly RF, Scott CJ.. "Enhanced antitumor activity of the photosensitizer meso-Tetra(N-methyl-4-pyridyl) porphine tetra tosylate through encapsulation in antibody-targeted chitosan/alginate nanoparticles.." Biomacromolecules. 2013: .

Fay F, McLaughlin KM, Small D, Fennell DA, Johnston PG, Longley DB, Scott CJ.. "Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery.." Biomaterials. 2011: .

Fay F, Scott CJ. "Antibody-targeted nanoparticles for cancer therapy. (review)." Immunotherapy. 2011: .

Donnelly RF, Morrow DI, Fay F, Scott CJ, Abdelghany S, Thakur R, Garland M, CJ, Woolfson AD.. "Microneedle-mediated Intradermal Nanoparticle Delivery: Potential for Enhanced Local Administration of Hydrophobic Pre-formed Photosensitisers.." Photodiagnosis and Photodynamic Therapy. 2010: .

Fay F, Scott CJ, McCarron PA.. "Innovation in particulate nanotechnology and implications for advanced visualisation and drug delivery. (review)." Current Nanoscience. 2010: .

Fay F, Quinn DJ, Gilmore BF, McCarron PA, Scott CJ.. "Gene delivery using dimethyldidodecylammonium bromide-coated PLGA nanoparticles.." Biomaterials. 2010: .

Fay F, Buick RJ, Olwill SA, Scott CJ.. "Targeted Nanoparticles. (review)." European BioPharmaceutical Review. 2008: .

McCarron PA, Marouf W, Quinn DJ, Fay F, Burden RE, Olwill S, Scott CJ.. "Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells.." Bioconjugate Chemistry. 2008: .

Presented Papers, Lectures, and Exhibitions and Performances

" " 2017: CUNY Nano Day.

" " 2016: Controlled Release Society Meeting.

" " 2015: World Molecular Imaging Congress.

" " 2015: New York Soft Nano symposium.

" " 2015: International Society for Magnetic Resonance in Medicine Meeting.

" " 2014: World Molecular Imaging Congress.

" " 2013: Nanotechnologies in Cancer Diagnosis, Treatment, and Prevention conference.

" " 2009: Joint Schools of Pharmacy Research seminar.


. 2013. Mass Production and Size Control of Nanoparticles Through Controlled Microvortices.. Patent WO 2013192310A1.

. 2011. Sialic acid coated nanoparticles as devices that can suppress pro-inflammatory immune response trough Siglec receptor pathway activation.. Patent WO/2011/073685.

Professional Honors, Prizes, Fellowships

Mount Sinai Future Leaders in Science Education and Communication Training Award: 2016.

Early Career Investigator travel award, New York Academy of Sciences: 2013.


Professional Staff Congress-CUNY Round 48, A microfluidic approach to generate multimodal contrast agents for atherosclerosis. 07/2017 - 07/2018: 3500 $.

Other Professional Activities and Public Service

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