Office Location: AC-4E03C
Degree Institution Field Dates PhD New York University MS University of Belgrade MS New York University BS University of Belgrade
The main focus of my laboratory is to understand events leading to programmed cell death (apoptosis) in developing T-cells in the thymus. We are currently using several genetically modified mice to determine the role of Beclin 1, a gene implicated in autophagy and apoptosis, in intrathymic T-cell development. My long term goal is to develop a mouse model in which the Beclin 1 gene will be inactivated in lymphoid cells. This will provide an excellent system to study different aspects of T-cell biology in which Beclin 1 could play an important role.
Areas of Expertise
T cell development
Articles in Field Of Expertise
Arsov I, Adebayo A, Kucerova-Levisohn M, Haye J, MacNeil M, Papavasiliou FN, Yue Z, Ortiz BD.. "A role for autophagic protein beclin 1 early in lymphocyte development." Journal of Immunology. 186(4) 2011: 2201-2209.
Hu Y, and Arsov, I.. "Nested Real-Time PCR for Hepatitis A detection.." Letters in Applied Microbiology. 49(5) 2009: 615-619.
Arsov I, Li X, Matthews G, Coradin J, Hartmann B, Simon AK, Sealfon SC, Yue Z.. "BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development." Cell Death & Differentiation. 15(9) 2008: 1385-1395.
National Institute of General Medical Sciences, Role of autophagy in T cell immune response. 2009-2013: .