Arsov, IvicaScience Advisor Food and Drug Administration, Northeast Regional Laboratory
Office Location: AC-4E03C
|PhD||New York University|
|MS||University of Belgrade|
|MS||New York University|
|BS||University of Belgrade|
The main focus of my laboratory is to understand events leading to programmed cell death (apoptosis) in developing T-cells in the thymus. We are currently using several genetically modified mice to determine the role of Beclin 1, a gene implicated in autophagy and apoptosis, in intrathymic T-cell development. My long term goal is to develop a mouse model in which the Beclin 1 gene will be inactivated in lymphoid cells. This will provide an excellent system to study different aspects of T-cell biology in which Beclin 1 could play an important role.
Areas of Expertise
T cell development
Articles in Field Of Expertise
Arsov I, Adebayo A, Kucerova-Levisohn M, Haye J, MacNeil M, Papavasiliou FN, Yue Z, Ortiz BD.. "A role for autophagic protein beclin 1 early in lymphocyte development." Journal of Immunology. 186(4) 2011: 2201-2209.
Hu Y, and Arsov, I.. "Nested Real-Time PCR for Hepatitis A detection.." Letters in Applied Microbiology. 49(5) 2009: 615-619.
Arsov I, Li X, Matthews G, Coradin J, Hartmann B, Simon AK, Sealfon SC, Yue Z.. "BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development." Cell Death & Differentiation. 15(9) 2008: 1385-1395.
National Institute of General Medical Sciences, Role of autophagy in T cell immune response. 2009-2013: .