Chang, Emmanuel

Overview

Curriculum Vitae

  1. Education


    Degree Institution Field Dates
    PhD  The Rockefeller University  Biochemistry  2006 
    BA  Princeton University  Chemistry  1999 
  2. Full-Time Academic Experience


    Institution Rank Field Dates
    York College/CUNY  Associate Professor  Chemsitry  2013-present 
    NYU Langone Medical Center  Visiting Scientist  Computational Biology  2016-2017 
    York College/CUNY  Assistant Professor  Chemistry  2006-2013 
    The Graduate Center/CUNY  Doctoral Faculty  Chemistry  2006-present 
    The Graduate Center/CUNY  Doctoral Faculty  Biochemistry  2008-present 
  3. Part-Time Academic Experience


    Institution Rank Field Dates
    The Rockefeller University  Adjunct Faculty  Mass Spectrometry  2006-2011 
  4. Non Academic Experience


  5. Employment Record At This Institution

  6. Publications In Field Of Expertise

    1. Books:
    2. Papers in Professional Journals:
      1. Articles:

        Dhital B, Durlik P, Rathod P, Gul-E-Noor F, Wang Z, Sun C, Chang EJ, Itin B, Boutis GS. "Ultraviolet Radiation Reduces Desmosine Cross-links in Elastin." Biochemical and Biophysical Reports. 10 2017: 172.

        Abdullah R, Patil KS, Pal R, Prabhudesai S, Lee S, Yang P, Panik K, Hoedt E, Basak I, Ho H-P, Chang EJ, Tzoulis C, Alves G, Neubert TA, Larsen JP, and Moller SG. "Subcellular alpha-synuclein Species Show Altered Behavior in Neurodegeneration." Molecular Neurobiology. 54 2017: 7639.

        Vedad J, Domarodzki M, Mojica E-RE, Chang EJ, Profit AA, Desamero RZB. "Conformational Differentiation of alpha-cyanohydroxycinnamic acid isomers: a Raman spectroscopic study." Journal of Raman Spectroscopy. 48 2017: 1282.

        Patil KS, Basak I, Pal R, Alves G, Ho H-P, Chang EJ, Larsen JP and Moller SG. "A Proteomics Approach to Investigate miR-153-3p and miR-205-5p targets in neuroblastoma cells." Plos One. 10 2015: e0143969.

        Papaioannou A, Louis M, Dhital B, Ho HP, Chang EJ, Boutis GS. "Quantitative Comparison of Structure and Dynamics of Elastin Following Three Isolation Schemes by 13C Solid State NMR and MALDI Mass Spectrometry." Biochimica et Biophysica Acta. 1854 2015: 391.

        Ho H-P, Rathod P, Louis M, Tada CK, Rahaman S, Mark KJ, Leng J, Dana D, Kumar S, Lichterfeld M, Chang EJ. "Studies on Quantitative Phosphopeptide Analysis by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry without Label, Chromatography or Calibration Curves." Rapid Communications in Mass Spectrometry. 28 2014: 2681.

        Leng J, Ho H-P, Buzon MJ, Pereyra F, Walker BD, Yu XG, Chang EJ, Lichterfeld M. "A Cell-Intrinsic Inhibitor of HIV-1 Reverse Transcription in CD4+ T Cells from Elite Controllers." Cell Host & Microbe. 15 2014: 717.

        Basak I, Pal R, Patil KS, Dunne A, Ho H-P, Lee S, Peiris D, Maple-Grodem J, Odell M, Chang EJ, Larsen JP, Moller SG. "Arabidopsis AtPARK13, Which Confers Thermotolerance, Targets Misfolded Proteins." Journal of Biological Chemistry. 289 2014: 14458.

        Dana D, De S, Rathod P, Davalos AR, Novoa DA, Paroly S, Torres VM, Afzal N, Lankalapalli RS, Rotenberg SA, Chang EJ, Subramaniam G, Kumar S. "Development of a Highly Potent, Selective and Cell-Active Inhibitor of Cysteine Cathepsin L-A Hybrid Design Approach." Chemical Communications. 50 2014: 10875.

        Wilson C, Ramai D, Serjanov D, Lama N, Levinger L, Chang EJ. "Tethered Domains and Flexible Regions in tRNase ZL, the Long Form of tRNaseZ." PLoS ONE. 8 2013: e66942.

        Dana D, Davalos AR, De S, Rathod P, Gamage RK, Huestis J, Afzal N, Zavlanov Y, Paroly SS, Rotenberg SA, Subramaniam G, Mark KJ, Chang EJ, Kumar S. "Development of Cell-Active Non-Peptidyl Inhibitors of Cysteine Cathepsins." Bioorganic & Medicinal Chemistry. 21 2013: 2975.

        Dana D, Das TK, Kumar I, Daalos AR, Mark KJ, Ramai D, Chang EJ, Talele TT, Kumar S. "Design, Synthesis and Evaluation of 2-(arylsulfonyl)oxiranes as Cell-permeable Covalent Inhibitors of Protein Tyrosine Phosphatases." Chemical Biology and Drug Design. 80 2012: 489.

        Westblade LF, Minakhin L, Tackett AJ, Kuznedelov K, Vvedenskaya I, Chang EJ, Wang Q, Mooney RA, Landick R, Chait BT, Severinov K, Darst SA. "Rapid Isolation and Identification of T4 Bacteriophage-Dependent Modifications of Escherichia coli RNA Polymerase using Immunoisolation and MALDI-MS." Journal of Proteome Research. 7 2008: 1244.

        Chang EJ, Begum, R Chait BT, Gaasterland T. "Predictive Computational Modeling of Cyclin-Dependent Kinase Substrates." PLoS ONE. 2 2007: e656.

        Chang EJ, Archambault V, McLachlin DT, Krutchinsky AN, Chait BT. "Analysis of Protein Phosphorylation by Hypothesis-Driven Multiple-Stage Mass Spectrometry." Analytical Chemistry. 76 2004: 4472.

        Archambault V, Chang EJ, Drapkin BJ, Cross FR, Chait BT, Rout MP. "Targeted Proteomic Study of the Cyclin-Cdk Module." Molecular Cell. 14 2004: 699.

        Hofmann RM, Cotton GJ, Chang EJ, Vidal E, Veach D, Bornmann W, Muir TW. "Fluorescent Monitoring of Kinase Activity in Real Time: Development of a Robust Fluorescence-Based Assay for Abl Tyrosine Kinase Activity." Bioorganic and Medicinal Chemistry Letters. 11 2001: 3091.

        Ha S, Chang E, Lo M, Men H, Park P, Ge M, Walker S. "The Kinetic Characterization of Escherichia coli MurG Using Synthetic Substrate Analogues." Journal of the American Chemical Society. 121 1999: 8415.

        Ko L, Ko EC, Nacharaju P, Liu W, Chang E, Kenessey A, Yen SC. "An Immunochemical Study on Tau Glycation in Paired Helical Filaments." Brain Research. 830 1999: 301.

      2. Proceedings:
        1. Refereed Proceedings
        2. Non-Refereed Proceedings
    3. Chapters in Books:
    4. Government Reports or Monographs
    5. Book Reviews:
  7. Other Publications

    1. Books:
    2. Papers in Professional Journals:
      1. Articles:
      2. Proceedings:
        1. Refereed Proceedings
        2. Non-Refereed Proceedings
    3. Chapters in Books:
    4. Government Reports or Monographs
    5. Book Reviews:
  8. Presented Papers, Lectures, And Exhibitions And Performances

  9. Patents

    None

  10. Work In Progress

    1. Books in progress:
    2. Papers in Progress:
    3. Papers submitted to journals for consideration:
    4. Research in progress:
  11. Professional Honors, Prizes, Fellowships

    Dean's Award for Undergraduate Research Engagement: 2014.

    Provost's Award for Undergraduate Research Engagement: 2013.

    Sigma Alpha Pi Excellence in Teaching Award: 2008.

    Burroughs-Wellcome Interfaces in Science Award: 1999-2003.

    American Institute of Chemists Award: 1999.

  12. Grants-In-Aid

    Professional Staff Congress-CUNY, The Role of Protein Phosphorylation in the Proliferation and Pathogenesis of Zika. 7/2017 - 8/2018: $6,000.

    Professional Staff Congress-CUNY, A Global Approach to the Discovery of HIV Protein Phosphorylation by Host Cell Kinases. 7/2015 - 6/2016: $6,000.

    Professional Staff Congress-CUNY, How is HIV Reverse Transcripatse Regulated by Cyclin Dependent Kianse Phosphorylation?. 7/2014- 6/2015: $3,500.

    Professional Staff Congress-CUNY, Regulation of HIV Reverse Transcriptase by Cyclin Dependent Kinase Phosphorylation. 7/2013 - 12/2014: $6,000.

    Professional Staff Congress-CUNY Round 42, Cyclin Specificity Using a Novel Mass Spectrometric Quantitative Mulitisite Phosphorylation Assay. 7/2011 - 12/2012: $6,000.

    ARRA Supplement to NIH MBRS SCORE Grant, Using isotope labeling/mass spectrometry to probe Cdk1 multisite phosphorylation dynamics. 10/2010 - 6/2012: $160,000.

    Collaborative Incentive Research Grant-CUNY, Round 16, Proteomic Analysis of Nup211p. 9/2010 - 8/2012: $60,000.

    Luitpold Pharmaceuticals, Pharmaceutical Compound Analysis. 1/2010- 12/2012: $750.

    Research Corporation Cottrell College Science Award, Investigating the gas phase chemistry of phosphorylated peptide ions using mass spectrometry. 2/2009 - 1/2011: $45,000.

    National Institutes of Health-MBRS/SCORE, Using isotope labeling/mass spectrometry to probe Cdk1 multisite phosphorylation dynamics. 1/2009 - 1/2012: $460,000.

    York College Auxiliary Enterprises, Developing Career Paths in Natural Science. 8/2007 - 12/2007: $700.

    Professional Staff Congress-CUNY, Round 39, Understanding mass spectrometric phosphopeptide behavior for bioanalytical methods development. 7/2008 - 6/2009: $5,000.

    Professional Staff Congress-CUNY, Round 38, Improving the computational prediction of cyclin-dependent kinase phosphorylation substrates. 7/2007 - 6/2008: $5,500.

    Research Equipment Grant-CUNY, Probing the dynamics of binding and catalysis in dihydropteridine reductase using a mT-jump stopped-flow device. 3/2007: $40,000.

    Graduate Research Technology Initiative-CUNY, Quantitative studies on protein interactions and phosphorylation using isoelectronic focusing and. 9/2006 - 8/2007: $120,000.

  13. Institutional Service

    1. Service to the Department

      Deputy Chair: 9/2017 - present.

      Chair, CLT search committee: 10/2015-5/2016.

      Department Curriculum Committee: 9/2013 - present.

      Department Academic Integrity Officer: 9/2010 - 12/2011.

      Senate: 9/2010 - 5/2015.

      Introductory Chemistry Committee: 9/2008 - present.

      Open House Organizer: 2007 - 2008.

      4 Faculty Search Committees: 2008 - present.

    2. Service to the School

      Committee on Governance, Secretary: 10/2017 - present.

      Commitee on Elections, Secretary: 10/2017 - present.

      Middle States Working Group Standard III: 2015 - present.

      Search Committee, VP of Student Development: 2015-2016.

      Curriculum Committee, Chair: 2014-2016; chair 2014-2015.

      Strategic Planning Committee: 2012-2013.

      Search Committee, Director of HR: 2011-2012.

      Task Force on General Education: 9/2010 - 5/2011.

      Bridges to Research Summer Program, Mentor and Seminar Speaker: Summers 2010, 2011, 2012.

      Junior Science & Humanities Symposium, Application review: 2010 and 2012.

      Pre-Graduate Advisory Committee for Science: 1/2009 - 9/2011.

      Council on Academic Advisement: 1/2008 - 2012.

      Pre-Medical/Pre-Dental Advisory Committee: 9/2007 - 2014.

      Coordinator of the Natural Sciences Seminar Series: 1/2007 - 5/2012.

      CUNY NYCSEF Supervisor: 7/2009 - 8/2009.

      Search Committee, Head of the York/FDA Collaboration: 2/2009 - 8/2009.

      Search Committee, Dean of Science and Mathematics: 5/2008 - 9/2008.

      Advisor to York College Chemistry Club: 9/2008 - 6/2009.

      York College Science Expo Reviewer/Judge/Chief Judge: 5/2007 - 5/2009.

      Louis Stokes Alliance for Minority Participation Steering Committee: 1/2007 - 6/2008.

    3. Service to the College
    4. Service to the Graduate Center

      Faculty Membership Committee, Biochemistry: 9/2014 - present.

      Alternate Deputy Representative, Biochemistry: 9/2014 - present.

      Executive Committee, Chemistry: 9/2009 - 6/2011.

      5 Thesis advisory committees: 9/2011 - present.

      Molecular Biophysics Second Level Exam Committees: 9/2008 - present.

      Analytical Chemistry Second Level Exam Committees: 1/2008 - present.

      ad hoc Committee on Governance, alternate: 9/2007.

    5. Service to the University

      ASRC Oversight Committee, Structural Biology Initiative Biological Mass Spectrometry Core Facility: Fall 2016 - present.

      PSC-CUNY Review Panel: 2009, 2013, 2014.

  14. Offices Held In Professional Societies

    Session organizer, Biological Spectroscopy, 44th Annual Middle Atlantic Regonal Meeting of the American Chemical Society: 5/2015.

    Board of Directors, Analytical Topical Group, New York Section of the American Chemical Society: 8/2008 - present.

    Session co-organizer, Biological Spectroscopy, 40th Annual Middle Atlantic Regional Meeting of the American Chemical Society, Bayside, NY: 5/2008.

  15. Other Professional Activities And Public Service

  16. Teaching Activities At This Institution

    1. Courses Taught (List)
      Course Description
      Chemistry 100  Chemical Calculations 
      Chemistry 101/109  Chemical Principles 1 
      Chemistry 102/111  Chemical Principles 2 
      Chemistry 341  Instrumental Analysis I 
      Chemistry/Biology 412  Biochemistry 
      Chemistry 421  Physical and Inorganic Chemistry Laboratory 
      Chemistry 450  Advanced Topics in Chemistry 
      Chemistry 460  Biochemistry 1 
      Chemistry 462  Experiments in Biochemistry 
      Chemistry 49X  Independent Study in Chemistry 
      Humanities 320  Honors Seminar: Problems of Race and Gender in the Scientific Enterprise 
      Graduate Center Biochem 77000  Physical Biochemistry 
      Graduate Center Biochem 711X0  Research Techniques in Biochemistry 
      Graduate Center Chem 80521  Advanced Seminar in Analytical Chemistry 
      Pharmaceutical Science 480  Independent Study in Pharmaceutical Science 
      Pharmaceutical Science 504  Advanced Biostatistics 
    2. New courses/programs developed (list):

      Chemical Calculations, hybrid, Chemistry 100.

      Advanced Biostatistics, hybrid, Pharmaceutical Science 504.

      Biochemistry 1, Biochemistry 2, Biochemistry Laboratory, Chem 460/461/462 Proposals - 2 semester Biochemistry lecture + 1 semester lab.

      Problems of Race and Gender in the Scientific Enterprise, Humanities 320 - Honors Seminar..