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Birk, Alexander

Overview

Curriculum Vitae

  1. Education


    Degree Institution Field Dates
    PhD  Cornell University  Pharmacology  1996-2000 
    BS  York College, CUNY  Chemistry  1991-1995 
  2. Full-Time Academic Experience


    Institution Rank Field Dates
    York College, CUNY  Assistant Professor  Bioenergetics and Pharmacology  08/28/2019 -- present 
    Weill Cornell Medical College  Assistant Professor  Bioenergetics and Pharmacology  2010 -- 2016 
    Institute for Hepatitis and Virus Research of Drexel University  Assistant professor  Virology and Pharmacology  2007 -- 2010 
    Weill Cornell Medical College  Instructor  Pharmacology and Biochgemistry  2004-2007 
  3. Part-Time Academic Experience


    Institution Rank Field Dates
    York College, CUNY  Adjunct Assistant Professor  Biology  2015 -- 2019 
  4. Non Academic Experience


  5. Employment Record At This Institution

    Rank Dates
    Assistant Professor  08/28/2019 
    Adjunct Assistant Professor  2015 --2019 
  6. Publications In Field Of Expertise

    1. Books:

      . . : , . .

    2. Papers in Professional Journals:
      1. Articles:

        Wayne Mitchell, Jeffrey D Tamucci, Emery L Ng, Shaoyi Liu, Alexander V Birk, Hazel H Szeto, Eric R May, Andrei Alexandrescu, and Nathan N Alder. "Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds." eLife. 11 2022: e75531.

        aXiaoping Zhu, Erika Aoyama, Alexander V. Birk, Oladapo Onasanya, William H. Carr, Lev Mourokh, Shelley D. Minteer, Michele Vittadello.. "Cytochrome c oxidase oxygen reduction reaction induced by cytochrome c T on nickel-coordination surfaces based on graphene oxide in suspension." Biochimica et Biophysica Acta - Bioenergetics. 1861(11) 2020: 148262-75.

        Ariza-Mateos A, Díaz-Toledano R, Block TM, Prieto-Vega S, Birk A*, Gómez.J. "Geneticin stabilises the open conformation of the 5' region of hepatitis C virus RNA and inhibits viral replication." J.Antimicrob Agents Chemother. 60(2) 2016: 925-35.

        H.H. Szeto, S. Liu, Y. Soong, A.V. Birk. "Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney." Am J Physiol Renal Physiol. 308 2015: F11-21.

        A.V. Birk, W.M. Chao, C. Bracken, J.D. Warren, H.H. Szeto. "Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis." Br J Pharmacol. 171 2014: 2017-2028.

        H.H. Szeto, A.V. Birk. "Serendipity and the discovery of novel compounds that restore mitochondrial plasticity." Clin Pharmacol Ther. 96 2014: 672-683.

        A.V. Birk, S. Liu, Y. Soong, W. Mills, P. Singh, J.D. Warren, S.V. Seshan, J.D. Pardee, H.H. Szeto. "The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin." J Am Soc Nephrol. 24 2013: 1250-1261.

        A. Ariza-Mateos, S. Prieto-Vega, R. Diaz-Toledano, A. Birk, H. Szeto, I. Mena, A. Berzal-Herranz, J. Gomez. "RNA self-cleavage activated by ultraviolet light-induced oxidation." Nucleic Acids Res. 40 2011: 1748-1766..

        D. Jiang, J.M. Weidner, M. Qing, X.B. Pan, H. Guo, C. Xu, X. Zhang, A. Birk, J. Chang, P.Y. Shi, T.M. Block, J.T. Guo. "Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections." J Virol. 84 2010: 8332-8341.

        X.G. Zhang, P.W. Mason, E.J. Dubovi, X. Xu, N. Bourne, R.W. Renshaw, T.M. Block, A.V. Birk. "Antiviral activity of geneticin against dengue virus." Antiviral Res. 83 2009: 21-27.

        R. Diaz-Toledano, A. Ariza-Mateos, A. Birk, B. Martinez-Garcia, J. Gomez. "In vitro characterization of a miR-122-sensitive double-helical switch element in the 5' region of hepatitis C virus RNA." Nucleic Acids Res. 37 2009: 5498-5510.

        A.V. Birk, E.J. Dubovi, L. Cohen-Gould, R. Donis, H.H. Szeto. "Cytoplasmic vacuolization responses to cytopathic bovine viral diarrhoea virus." Virus Res. 2008 132: 76-85.

        A.V. Birk, E.J. Dubovi, X. Zhang, H.H. Szeto. "Antiviral activity of geneticin against bovine viral diarrhoea virus." Antivir Chem Chemother. 19 2008: 33-40.

        K. Zhao, G.M. Zhao, D. Wu, Y. Soong, A.V. Birk, P.W. Schiller, H.H. Szeto. "Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury." J Biol Chem. 279 204: 34682-34690.

        A. V. Birk, W. N. Chao, S. Liu S, Y. Soong Y, H. H Szeto. "Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia." Biochim Biophys Acta. 10 2015: 1075-1084.

      2. Proceedings:
        1. Refereed Proceedings
        2. Non-Refereed Proceedings
    3. Chapters in Books:
    4. Government Reports or Monographs
    5. Book Reviews:
  7. Other Publications

    1. Books:
    2. Papers in Professional Journals:
      1. Articles:
      2. Proceedings:
        1. Refereed Proceedings
        2. Non-Refereed Proceedings
    3. Chapters in Books:
    4. Government Reports or Monographs
    5. Book Reviews:
  8. Presented Papers, Lectures, And Exhibitions And Performances

  9. Patents

    Alexander V. Birk and Margaret MacNeil. . Cationically-enframed high density aromatic peptides. Patent pending, filed 2019, and issued pending.

    . D. Travis Wilson, Hazel H. Szeto, and Alexander V. Birk. 2014. Aromatic cationic peptides and uses of same. Patent 20140378396..

    . D. Travis Wilson, Hazel H. Szeto, and Alexander V. Birk. 2014. Aromatic cationic peptides and uses of same. Patent 20140349941.

    . D. Travis Wilson, Hazel H. Szeto, and Alexander V. Birk. 2014. Aromatic cationic peptides and uses of same. Patent 20140093897..

    Hazel H. Szeto, Kesheng Zhao, Hugh D. Robertson, Alexander V. Birk. 2010. Method and carrier complexes for delivery molecules to cells.. Patent 20130085259.

    Pardee Joel D, Birk Alexander V. 2009. Metabolic enhancement therapy. Patent WO 2009/051609.

    Birk Alexander V, Dubovi Edward J, Szeto Hazel H. 2008. 2-amino-2,7-dideoxy-alpha-D-glycero-D-gluco-heptopyranosyl inhibitors of positive sense single-stranded RNA envelope viruses. Patent WO 2008/154373.

  10. Work In Progress

    1. Books in progress:
    2. Papers in Progress:
    3. Papers submitted to journals for consideration:
    4. Research in progress:
  11. Professional Honors, Prizes, Fellowships

  12. Grants-In-Aid

    CUNY Junior Faculty Research Award Fall 2019, UNDERSTANDING MECHANISM OF ACTION OF NOVEL MITOCHONDRIA-TARGETED HIGH DENSITY AROMATIC PEPTIDES. pending: $50,000.00.

    PSC CUNY Research Award Program Fall 2019, ROLE OF CARDIOLIPIN IN TARGETING NOVEL HIGH DENSITY AROMATIC PEPTIDES TO MITOCHONDRIA. pending: 6,000.00.

  13. Institutional Service

    1. Service to the Department
    2. Service to the School
    3. Service to the College

      Principal Coordinator, Clinical Trial Management Master’s Program: 08/28/2019 -- present.

    4. Service to the Graduate Center
    5. Service to the University
  14. Offices Held In Professional Societies

  15. Other Professional Activities And Public Service

  16. Teaching Activities At This Institution

    1. Courses Taught (List)
      Course Description
      Bio234 29907  Anatomy and Physiology lecture 
      Bio234 29913  Anatomy and Physiology lab 
      CTM503 60861  Clinical Trial Management 
      Bio491 67705  Independent Study 
    2. New courses/programs developed (list):