Yan, H., Zareen, N., and Levinger, L. 2006. Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the tRNase Z cleavage site, processing kinetics and substrate secondary structure. J. Biol. Chem. 281: 3926-3935.

Hua Yan, a MS-level research technician who subsequently matriculated in the PhD program at Mt. Sinai School of Medicine, analyzed naturally occuring substitutions in a mitochondrial tRNA to determine the effects on pre-tRNA 3' end processing by tRNase Z. Some of these mutations are associated with maternally transmitted diseases including non-syndromic deafness. Additionally, Hua found that of the two forms of tRNase Z encoded in the human genome, the long form has almost 2,000-fold greater catalytic efficiency than the short form. Yan, H., Zareen, N., and Levinger, L. 2006. Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the tRNase Z cleavage site, processing kinetics and substrate secondary structure. J. Biol. Chem. 281: 3926-3935.

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