Levinger, Louis
- Overview
- Curriculum Vitae
Biotechnology Coordinator, MARC Program Director
Professor
Biology
Phone: 718-262-2704
Office Location: AC-4E03
louie@york.cuny.edu
http://york.cuny.edu/Members/llevinger/
- Education:
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Degree Institution Field Dates PhD University of North Carolina, Chapel Hill Biochemistry 1978 BS Antioch College Biology 1973
Dr. Levinger studies RNA-Protein interactions using biochemistry and molecular biology. The reaction he investigates is the 3 end processing of tRNA precursors. All RNAs are transcribed as precursors and undergo maturation. Mature tRNAs are essential for protein synthesis. In this research project we construct mutations in both the enzyme and substrate and analyze their effects on this important reaction.
- Areas of Expertise:
- Biochemistry
Molecular Biology
Enzymology
Biotechnology
Nucleic Acid-Protein Interactions
- Articles in Field Of Expertise:
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Levinger L, O Jacobs*, M James*.. "In vitro 3' end endonucleolytic processing defect in a human mitochondrial tRNASer(UCN) precursor with the U7445C substitution, which causes non-syndromic deafness." Nucleic Acids Research. 29 2001: 4334-4340.
Levinger, L., Giegé, R., Florentz, C. "Pathology-related substitutions in human mitochondrial tRNAIle reduce precursor 3' end processing efficiency in vitro." Nucleic Acids Research. 31 2003: 1904-1912.
Yan, H., Zareen, N., and Levinger, L.. "Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the tRNase Z cleavage site, processing kinetics and substrate secondary structure." J. Biol. Chem.. 281 2006: 3926-3935.
Zareen, N., Hopkinson, A.*, Levinger, L.. "Residues in two homology blocks on the amino side of the tRNase Z His domain contribute unexpectedly to pre-tRNA 3’ end processing." RNA. 12 2006: 1104-1115.
Karkashon, S., Hopkinson, A, and Levinger, L.. "tRNase Z Catalysis and Conserved Residues on the Carboxy Side of the His Cluster." Biochemistry. 46 2007: 9380-9387.
- Professional Honors, Prizes, Fellowships:
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Sabbatical Fellowship: 2001-2002.