Office Location: AC-4E03E
Degree Institution Field Dates PhD Saga Medical School, Japan Neurophysiology 1993 MS Second Military Medical University, China Neurophysiology 1986 BS Shanxi Medical School, China Medicine 1983
Using the techniques of electrophysiological recording and microinjection, Dr. Hua studies synaptic transmission, the means by which neurons communicate with each other. She is particularly interested in the speed of neuronal communication and theories on the signal processing capacity of neural networks. More recently, Dr. Hua started a project on the structural mechanism of human autism spectrum disorders. With several mutants of a Drosophila modal of human autism, she is trying to quantify the microstructural changes in the mutants’ neural synapses.
Areas of Expertise
Articles in Field Of Expertise
Hua S-Y, Syed A, Aupérin TC & Tong L. "The cytoplasmic domain of rat synaptotagmin I enhances synaptic transmission." Cellular and Molecular Neurobiology. 34: 659-667, 2014.
Venkatesh TR, Wise A, Schatoff E, Flores J, Ueda A, Hua S-Y & Wu C-F. "Drosophila-Cdh1(Rap/Fzr), a regulatory subunit of APC/C is required for synaptic morphology, synaptic transmission and locomotion.." International Journal of Developmental Neuroscience. 31: 624-633, 2013.
Yoon AC, Kathpalia V, D’Silva S, Cimenser, A & Hua S-Y. "Determining Ca2+ - sensor binding time and its variability in evoked neurotransmitter release." Journal of Physiology (London). 586: 1005-1015, 2008.
Hua S-Y, Teylan M & Cimenser A. "An antibody to synaptotagmin I facilitates synaptic transmission." European Journal of Neuroscience. 25: 3217-3225, 2007.
Troncone LR, Georgiou J, Hua S-Y, Elrick D, Lebrun I, Magnoli F & Charlton MP. "Promiscuous and reversible blocker of presynaptic calcium channels in frog and crayfish neuromuscular junctions from Phoneutria nigriventer spider venom." Journal of Neurophysiology. 90: 3529-3537, 2003.
Hua S-Y, Liu C, Nohmi M & Kuba K. "Modes of propagation of Ca2+ -induced Ca2+ release in bullfrog sympathetic ganglion cells." Cell Calcium. 27: 195 204, 2000.
Nohmi M, Hua S-Y, Liu C & Kuba K. "Ryanodine- and thapsigargin-insensitive Ca2+-induced Ca2+ release primed by lowering external Ca2+ in rabbit autonomic neurons." Pflügers Archiv European Journal of Physiology. 440: 588 599, 2000.
Hua S-Y & Charlton MP. "Partial VAMP complexes revealed by stimulus dependent action of tetanus toxin." Nature Neuroscience. 2: 1078-1083, 1999.
Hua S-Y, Raciboska DA, Trimble WS & Charlton MP. "Different VAMP/synaptobrevin complex for spontaneous and evoked transmitter release at the crayfish neuromuscular junction." Journal of Neurophysiology. 80: 3233-3247, 1998.
Yoshizaki K, Hoshino T, Sato M, Koyano H, Nohmi M, Hua S.-Y., and Kuba, K. "Ca2+-induced Ca2+ release and its activation in response to a single action potential in rabbit otic ganglion cells." Journal of Physiology (London). 486: 177-178, 1995.
Hua S-Y, Tokimasa T, Takasawa S, Furuya Y, Nohmi M, Okamoto H. & Kuba K. "Cyclic ADP-ribose modulates Ca2+ release channels for activation by physiological Ca2+ entry in bullfrog sympathetic neurons." Neuron. 12: 1073-1079, 1994.
Kuba k, Hua S-Y & Hayashi T. "A UV laser-scanning confocal microscope for the measurement of intracellular Ca2+." Cell Calcium. 16: 205-218, 1994.
Hua SY, Nohmi M & Kuba K.. "Characteristics of Ca2+ release induced by Ca2+ influx in cultured bullfrog sympathetic neurons." Journal of Physiology (London). 464: 245-272, 1993.
Nohmi M, Hua S-Y & Kuba K. "Intracellular calcium dynamics in response to action potentials in bullfrog sympathetic ganglion cells." Journal of Physiology (London). 458: 171-190, 1992.
Nohmi M, Hua S-Y & Kuba K. "Basal Ca2+ and the oscillation of Ca2+ in caffeine-treated bullfrog sympathetic neurons." Journal of Physiology (London). 450: 513-528, 1992.
Kuba K, Hua S-Y & Nohmi M. "Spatial and dynamic changes in intracellular Ca2+ measured by confocal laser-scanning microscopy in bullfrog sympathetic ganglion cells." Neuroscience Research. 10: 245-259, 1991.
Nohmi M, Kuba K & Hua S-Y. "Ultraviolet light activates blocking actions of dantrolene on intracellular Ca2+ release in bullfrog sympathetic neurons." Journal of Biological Chemistry. 262: 22254-22259, 1991.
Hua S-Y & Chen Y-Z. "Membrane receptor-mediated electrophysiological effects of glucocorticoid on mammalian neurons." Endocrinology. 124: 687-691, 1989.
Reviews in Field Of Expertise
"Fluorescent and Luminescent Probes for Biological Activity: A Practical Guide to Technology for Quantitative Real-Time Analysis" : 16:533, 1992.
Presented Papers, Lectures, and Exhibitions and Performances
" The protein machinery for neurotransmitter release " February 18, 2015: St Johns University.
" Ultrastructural defects in neuromuscular synapses of Drosophila mutants: an animal model of autism spectrum disorders " November, 2014: Annual Biomedical Research Conference for Minority Students.
" Drosophila-Cdh1 (Rap/Fzr) a regulatory subunit of APC/C plays an important role in synaptogenesis, synaptic transmission and locomotion " October. 3-7, 2011: Neurobiology of Drosophila at Cold Spring Harbor Laboratory, New York.
" The cytoplasmic domain of rat synaptotagmin I facilitates synaptic transmission in vivo " April 13, 2011: Conference: Synapses: From Molecules to Circuits & Behavior.
" SNAREs and synaptotagmin – proteins devoted to speed of neuronal communications " March 22, 2010: Department of Psychology, Queens College/CUNY.
" How fast can neurons talk – the role of synaptotagmin in neurotransmitter release " March, 2007: Department of Biology, St. Mary’s College.
" The calcium-dependent and calcium-independent components of synaptic delay at crayfish neuromuscular synapses " October, 2004: 34th Annual Meeting of Society for Neuroscience, San Diego.
" The dependence of synaptic delay on calcium influx in crayfish neuromuscular junctions " November, 2003: 33rd Annual Meeting of Society for Neuroscience, New Orleans.
" The molecular mechanisms of transmitter release latency " February 26, 2002: Department of Biology, Columbia University.
" Partial SNARE complex in Neurotransmitter release revealed by activity-dependent action of clostridial neurotoxin " January 31, 2000: MRC Periodental Physiology Group, Toronto, Canada.
Professional Honors, Prizes, Fellowships
Auxiliary Enterprises RFP Award: Spring 2015.
Auxiliary Enterprises RFP Award: Fall 2014.
Director’s Award, 5th Annual Undergraduate Research Day: Spring 2014.
Auxiliary Enterprises RFP Award: Spring 2014.
Auxiliary Enterprises RFP Award: Fall 2013.
Stewart Travel Award: April 14, 2011.
CUNY, PSC TRADA-46. July 1, 2015 - June 30, 2016: $ 3,500.
CUNY, PSC TRADA-44. July 1, 2013 - June 30, 2014: $ 3,500.
CUNY, PSC TRADA-43. July 1, 2012 - June 30, 2013: $ 3,500.
CUNY, GEP Grant Writing Assistance Program. Spring 2009: $ 0.
Other Professional Activities and Public Service
Faculty advisor for the York College Meditation-Yoga Club: Spring 2010 - 2011.
Faculty advisor for the Chinese Student Association of York College: 2009 - 2012.
Peer reviewer of NSF grant: 2006.