Office Location: AC-3F05
Degree Institution Field Dates PhD City University of New York Experimental Cognition 1997 BA City College, City University of New York Psychology 1979
My research interest is based on using rodent models of Alzheimer’s disease and the recovery of cognitive functions. The rat Alzheimer’s model is produced by chronic infusion of neurotoxins. I am interested in the effects of intracranial self-stimulation and deep brain stimulation in an animal model of Alzheimer’s disease and its effects on attention/learning/memory and neurogenesis. My lab uses various behavioral assessments including the Social Discrimination test, Morris water maze for testing learning/memory, and a ‘serial reaction time task’ for the testing of attention.
Currently, I am looking at the behavioral and cognitive deficits, as well as sleep-wake measures in streptozotocin-induced [neurotoxin] rats. The goal of this study is to identify the biomarkers of Alzheimer's disease and measure changes in sleep/wake patterns in rodents.
Areas of Expertise
- Behavioral Neuroscience
Central mechanisms of reward and Sleep
Articles in Field Of Expertise
Hungund, B. L., Goldstein, D. B., Villegas, F. & Cooper, T. B.. "Formation of fatty Acids ethyl esters during chronic ethanol treatment in mice." Biochemical Pharmacology. 37 1988: 3001-3004.
Villegas, Franciso. "Effects of Ad Libitum Midbrain Intracranial Self-Stimulation on Rapid Eye Movement Sleep in Rats." Unpublished Doctoral Dissertation. 1997: .
Abel, M. S., Villegas, F., Steiner, S. S., Beer, B. & Meyerson, L. R.. "The effect of rapid eye movement sleep deprivation on cortical ß-adrenergic rapid eye movement sleep deprivation on cortical adrenergic receptors." Brain Research. 11 1983: 792-794.
Presented Papers, Lectures, and Exhibitions and Performances
" Rodriguez, B., Verdieu, Y. C., Anderson, M. & Villegas, F. 5-HT7 Agonist AS-19 and Antagonist SB-269970 on a Spatial Navigational Memory Task in Male Long-Evans Rats " 2007: Annual Biomedical Research Conference for Minority Students. Austin, TX..
" Parasram, Y. L., Rodriguez, I., Fiorucci, J., Liz, G., Castrillon, N., Gómez-Blum, L. & Villegas, F. Various Doses of Methylene Blue on Radial Maze Acquisition in Rats " 2005: Annual Meeting of Society for Neuroscience. Washington, DC..
" Hungund, B. L., Villegas, F. & Mahadik, S. P. Ganglioside reduces ethanol-induced sleep in mice " 1987: American Society for Neurochemistry.
" Gimino, F., Villegas, F., Murphy, P., Ocheret, D., Bashir, T., Alvarez, R., Abreau, J., Steiner, S. S., & Ellman, S. J. Clonidine blocks the effect of morphine on intracranial self-stimulation rates from the medial forebrain bundle and the locus coeruleus " 1986: Annual Meeting of Society for Neuroscience. Washington, D.C..
" Villegas, F., Steiner, S. S., Abreau, J., Gimino, F., Beer, B. & Meyerson, L. R. Non correspondence of rapid eye movement sleep deprivation and cortical ß-adrenergic receptor regulation " 1982: Annual Meeting of Society for Neuroscience. Minneapolis, MN..
" Villegas, F., Gimino, F., Alvarez, R., Abreau, J., Sano, M., Steiner, S. S. & Ellman, S. J. Morphine Differently affects ICSS interactions between the locus coeruleus and the medial forebrain bundle. " 1981: Annual Meeting of the Society for Neuroscience, Los Angeles, CA..
" Villegas, F., Gimino, F., Abreau, J. & Steiner, S. S. Parametics variations in ICSS: Constant current and isolations from ground " 1980: MBRS Conference.
" Halperin, R., Halperin, J., Villegas, F., Daren, S., Steiner, S. S. & Ellman, S. J. The effects of REM sleep deprivation on stimulus-bound eating thresholds " 1977: Annual Meeting of Society for Neuroscience. Anaheim, CA..
Other Professional Activities and Public Service
American Association for the Advancement of Science : .
Eastern Psychological Association: .
Society for Neuroscience: .
U. S. Air force: 1968 – 1972.