Chakravarti, Deb

Overview

Curriculum Vitae

  1. Education


    Degree Institution Field Dates
    PhD  University of Oxford  Protein Chemistry/Immunochemistry  1982 
    PhD  University of Calcutta  Biochemistry  1979 
    MS  University of Calcutta  Biochemistry  1974 
    BS  University of Calcutta  Chemistry  1972 
  2. Full-Time Academic Experience


    Institution Rank Field Dates
    Keck Graduate Institute of Applied Life Sciences  Arnold and Mabel Beckman Professor and Director of Proteomics  Biotech, Regulatory affairs and Proteomics  2002 - 2009 
    University of Alabama at Birmingham  Assistant Professor of Medicine  Vaccine & Parasitic Diseases  1989 - 1994 
    Research Institute of Scripps Clinic (TSRI)  Senior Research Fellow  Immunology  1983 - 1988 
  3. Part-Time Academic Experience


  4. Non Academic Experience


    Place of Employment Title Date
    Wyeth Vaccines (Pfizer)  Principal Research Scientist II  1999 - 2002 
    Wyeth Vaccines (Pfizer)  Senior Research Scientist II  1994 - 1999 
  5. Employment Record At This Institution

    Rank Dates
    Professor of Chemistry; Director, York College-US FDA Partnership & Director, Phrmaceutical Sciences Program  2010 - Present 
  6. Publications In Field Of Expertise

    1. Books:
    2. Papers in Professional Journals:
      1. Articles:

        B. Chakravarti, B. Mallik, and D.N. Chakravarti. "Proteomics and Systems Biology – Application in Drug Discovery and Development." Methods Mol. Biol. 662, 2010: 3-28.

        B. Chakravarti, P. Fathy, M. Sindicich, B. Mallik and D. N. Chakravarti. "Comparison of SYPRO Ruby and Flamingo fluorescent stains for application in proteomic research." Anal. Biochem. 398, 2010: 1-6.

        F. Kalinec, P. Webster, A. Maricle, D. Guerrero, D. N. Chakravarti, B. Chakravarti, R. Gellibolian and G. Kalinec. "Glucocorticoid-stimulated, transcription independent release of Annexin A1 by Cochlear Hensen Cells." Br. J. Pharmacol. 158, 2009: 1820-1834.

        B. Chakravarti, B. Seshi, W. Ratanaprayul, N. Dalal, L. Lin, A. Raval and D. N. Chakravarti. "Proteome profiling of aging in mouse models. Differential expression of proteins involved in metabolism, transport and stress response in kidney." Proteomics. 9, 2009: 580-597.

        B. Chakravarti, A. Raval, S. Gallagher and D. N. Chakravarti. "A highly uniform UV transilluminator: A new system without the need of software correction." BIOforum Europe. 12, 2008: 38-39.

        B. Chakravarti, M. Louie, W. Ratanaprayul, S. Gallagher and D. N. Chakravarti. "A highly uniform UV transillumination imaging system for quantitative analysis of nucleic acids and proteins." Proteomics. 8, 2008: 1789-1797.

        B. Chakravarti, W. Ratanaprayul, N. Dalal and D. N. Chakravarti. "Comparison of SYPRO Ruby and Deep Purple using commonly available UV transilluminator: wide-scale application in proteomic research." J. Proteome Res. 7, 2008: 2797-2802.

        B. Chakravarti, M. Oseguera, N. Dalal, P. Fathy, B. Mallik, A. Raval and D. N. Chakravarti. "Proteomic profiling of aging in the mouse heart: Altered expression of mitochondrial proteins." Arch. Biochem. Biophys. 474, 2008: 22-31.

        B. Chakravarti and D.N. Chakravarti. "Oxidative modification of proteins: age-related changes." Gerontology. 53, 2007: 128-139.

        B. Chakravarti, S. Lewis, D. N. Chakravarti and A. Raval. "Resolution of three dimensional structure of proteins and protein complexes from chemical cross-linking and mass spectrometry: A biochemical and computational overview." Current Proteomics. 3, 2006: 1-21.

        N. Gupta, A. Law, R. Poddar, M. Louie, A. Ray and D.N. Chakravarti. "Toxicoproteomics: Applications in drug development." Current Proteomics. 2, 2005: 97-102.

        A. Law, N. Gupta, M. Louie, R. Poddar, A. Ray and D.N. Chakravarti. "Identification and characterization of plant allergens using proteomic approaches." Current Proteomics. 2, 2005: 147-164.

        D.N. Chakravarti, S. Gallagher and B. Chakravarti. "Difference gel electrophoresis: Application in quantitative proteomics research." Current Proteomics. 1, 2004: 261-271.

        A. Rajan, J. Mullen, N. Bhatnagar, A. Dubey, A. Niemz, B. Chakravarti and D.N. Chakravarti. "Micro-parallel liquid chromatography for analysis of peptides and proteins." JALA. 9, 2004: 312-317.

        D.N. Chakravarti. "From the decline and fall of protein chemistry to proteomics." Biotechniques. Mar Suppl 2002: 2-3.

        D.N. Chakravarti, B. Chakravarti and I. Moutsatsos. "Informatic tools for proteome profiling." Biotechniques. Mar Suppl 2002: 4-10, 12-15.

        D.N. Chakravarti, M.J. Fiske, L.D. Fletcher and R.J. Zagursky. "Application of genomics and proteomics for identification of bacterial gene products as potential vaccine candidates." Vaccine. 19, 2001: 601-612.

        D.N. Chakravarti, M.J. Fiske, L.D. Fletcher and R. Zagursky. "Mining Genomes and Mapping Proteomes: Identification and Characterization of Protein Subunit Vaccines." Dev. Biol. 103, 2000: 81-90.

        D. Chen, J.C. McMichael, K.R. VanDerMeid, A.W. Masi, E. Bortell, J.D. Caplan, D.N. Chakravarti and V.L. Barniak. "Evaluation of a 74-kDa transferrin-binding protein from Moraxella (Branhamella) catarrhalis as a vaccine candidate." Vaccine. 18, 2000: 109-118.

        A.A. Shukla, R.L. Hopfer, D.N. Chakravarti, E. Bortell and S.M. Cramer. "Purification of an antigenic vaccine protein by selective displacement chromatography." Biotechnol. Prog. 14, 1998: 92-101.

        J.C. McMichael, M.J. Fiske, R.A. Fredenburg, D.N. Chakravarti, K.R. VanDerMeid, V. Barniak, J. Caplan, E. Bortell, S. Baker, R. Arumugham and D. Chen. "Isolation and characterization of two proteins from Moraxella catarrhalis that bear a common epitope." Infect. Immun. 66, 1998: 4374-4381.

        B. Chakravarti, D.N. Chakravarti, J. Devecis, B. Seshi and G.N. Abraham. "Effect of age on mitogen induced protein tyrosine phosphorylation in human T cell and its subsets: down-regulation of tyrosine phosphorylation of ZAP-70." Mech. Ageing Dev. 104, 1998: 41-58.

        B. Chakravarti, D.N. Chakravarti and H.J. Muller-Eberhard. "Purification and characterization of a phagocytosis inducing factor: Role in cell-substratum adherence." Biochem. Biophys. Res. Commun. 243, 1998: 591-597.

        B. Chakravarti, S. Lagoo-Deenadayalan, J.S. Parker, D.R. Whitfield, A. Lagoo and D.N. Chakravarti. "In vivo molecular analysis of cytokines in a murine model of ocular onchocerciasis: Up-regulation of IL-4 and IL-5 mRNAs and not IL-2 and IFN mRNAs in the cornea due to experimental interstitial keratitis." Immunol. Letts. 54, 1996: 59-64.

        B. Chakravarti, B.M. Greene, S.K. Dey, J.S. Parker, T.R. Unnasch, T.A. Herring, A. Gbakima, M.L. Eberhard and D.N. Chakravarti. "Onchocerca volvulus: Expression and purification of recombinant antigen RAL2 - Studies on immunogenicity and pathogenicity." Biochem. Arch. 12, 1996: 55-69.

        B. Chakravarti, J.H. Lass, E. Diaconu, C.E. Roy, T.A. Herring, D.N. Chakravarti and B.M. Greene. "Characterization of native pathogenic antigens of Onchocerca volvulus: Identification of high molecular mass protein antigens eliciting interstitial keratitis in a guinea pig model." Exp. Eye Res. 60, 1995: 347-358.

        B. Chakravarti, T.A. Herring, J.H. Lass, J.S. Parker, R.P. Bucy, E. Diaconu, J. Tseng, D.R. Whitfield, B.M. Greene and D. N. Chakravarti. "Infiltration of CD4+ T cells into cornea during development of Onchocerca volvulus-induced experimental sclerosing keratitis in mice." Cell. Immunol. 159, 1994: 306-314.

        B. Chakravarti, D.N. Chakravarti and H.J. Muller-Eberhard. "Role of de novo protein synthesis by mononuclear leukocytes in opsonin-independent phagocytosis." Cell. Immunol. 154, 1994: 134-142.

        B. Chakravarti, J.H. Lass, D.S. Bardenstein, E. Diaconu, C.E. Roy, T.A. Herring, D.N. Chakravarti and B.M. Greene. "Immune-mediated Onchocerca volvulus sclerosing keratitis in the mouse." Exp. Eye Res. 57, 1993: 21-27.

        D.N. Chakravarti, B. Chakravarti, C.A. Parra and H.J. Muller-Eberhard. "Structural homology of complement protein C6 with other channel-forming proteins of complement." Proc. Natl. Acad. Sci. (USA). 86, 1989: 2799-2803.

        D.N. Chakravarti and H.J. Muller-Eberhard. "Biochemical characterization of the human complement protein C6: association with -thrombin-like enzyme and absence of serine protease activity in cytolytically active C6." J. Biol. Chem. 263, 1988: 18306-18312.

        R.G. DiScipio, D.N. Chakravarti, H.J. Muller-Eberhard and G.H. Fey. "The structure of human complement component C7 and the C5b-7 complex." J. Biol. Chem. 263, 1988: 549-560.

        D.N. Chakravarti, R.D. Campbell and R.R. Porter. "The chemical structure of the C4d fragment of the human complement component C4." Mol. Immunol. 24, 1987: 1187-1197.

        B. Chakravarti and D.N. Chakravarti. "Phagocytosis: An overview." Pathol. Immunopathol. Res. 6, 1987: 316-342.

        D.N. Chakravarti, B. Chakravarti and P. Chakrabarti. "Studies on phospholipase activities in Saccharomyces cerevisiae." Biochem. Arch. 3, 1987: 61-67.

        D.N. Chakravarti and T. Kristensen. "Recent advances in the study of the molecular structure of the complement proteins." Pathol. Immunopathol. Res. 5, 1986: 317-351.

        D.N. Chakravarti, R.D. Campbell and J. Gagnon. "Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4." FEBS Letters. 154, 1983: 387-390.

        D.N. Chakravarti, B. Chakravarti and P. Chakrabarti. "Studies on phospholipase activities in Neurospora crassa conidia." Arch. Biochem. Biophys. 206, 1981: 392-402.

        D.N. Chakravarti, B. Chakravarti and P. Chakrabarti. "Incorporation of photolabile azido fatty acid probes in Neurospora crassa and Saccharomyces cerevisiae." Experientia. 37, 1981: 353-354.

        D.N. Chakravarti, B. Chakravarti and P. Chakrabarti. "Studies on Phospholipase activities in Neurospora crassa mycelia." Lipids. 15, 1980: 830-837.

        D.N. Chakravarti, B. Chakravarti and P. Chakrabarti. "Studies on disruption of Saccharomyces cerevisiae cells in the modified Eaton press." J. Inst. Chem. 52, 1980: 239-240.

        D.N. Chakravarti, B. Chattopadhyay, P. Chakrabarti, D. Mukherji and D. Chakravarti. "A modified Eaton press for disruption of yeast cells." J. Inst. Chem. 50, 1978: 94-97.

      2. Proceedings:
        1. Refereed Proceedings
        2. Non-Refereed Proceedings
    3. Chapters in Books:

      D.N Chakravarti, B. Chakravarti, and B. Mallik. "Reagent Preparation: Theoretical and Practical Discussions." Current Protocols in Essential Laboratory Techniques, Eds. S. Gallagher, E. Wiley. John Wiley & Sons, New Jersey. UNIT 3.1. Second edition. 2012: 3.1.1-3.1.14.

      E.A. Wiley, D.N. Chakravarti, and K.M. Slade. "Measurement of pH." Current Protocols in Essential Laboratory Techniques, Eds. S. Gallagher, E. Wiley. John Wiley & Sons, New Jersey. UNIT 3.2. Second edition. 2012: 3.2.1-3.2.17.

      B. Mallik, B. Chakravarti, and D.N. Chakravarti. "Overview of Chromatography." Current Protocols in Essential Laboratory Techniques, Eds. S. Gallagher and E. Wiley. John Wiley & Sons, New Jersey. UNIT 6.1. Second edition. 2012: 6.1.1-6.1.10.

      B. Chakravarti, B. Mallik, and D.N. Chakravarti. "Column Chromatography." Current Protocols in Essential Laboratory Techniques, Eds. S. Gallagher, E. Wiley: in Current Protocols in Essential Laboratory Techniques Online (accompanying online supplement to the Second edition), John Wiley & Sons, New Jersey. UNIT 6.2. Second edition: accompanying online supplement. 2012: 6.2.1-6.2.14.

      D.N. Chakravarti, B. Chakravarti and B. Mallik. "Reagent Preparation: Theoretical and Practical Discussions." Current Protocols in Essential Laboratory Techniques, Eds. S. Gallagher and E. Wiley, John Wiley & Sons, New Jersey. UNIT 3.1. 2008: 3.1.1-3.1.13.

      E.A. Wiley and D.N. Chakravarti. "Measurement of pH." Current Protocols in Essential Laboratory Techniques, Eds. S. Gallagher and E. Wiley, John Wiley & Sons, New Jersey. UNIT 3.2. 2008: 3.2.1-3.2.12.

      B. Mallik, B. Chakravarti and D.N. Chakravarti. "Overview of Chromatography." Current Protocols in Essential Laboratory Techniques, Eds. S. Gallagher and E. Wiley. John Wiley & Sons, New Jersey. UNIT 6.1. 2008: 6.1.1-6.1.22.

      B. Chakravarti, B. Mallik and D.N. Chakravarti. "Column Chromatography." Current Protocols in Essential Laboratory Techniques, Eds. S. Gallagher and E. Wiley, John Wiley & Sons, New Jersey. UNIT 6.2. 2008: 6.2.1-6.2.14.

      B. Chakravarti, S. Gallagher and D.N. Chakravarti. "Difference gel electrophoresis (DIGE) using CyDye DIGE fluor minimal dyes." Current Protocols in Molecular Biology, Eds. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl. John Wiley & Sons, New York. 2005: 10.23.1-10.23.8.

      B. Chakravarti and D.N. Chakravarti. "Protein phosphorylation in T-cell signaling: effect of age." Advances in Cell Aging and Gerontology, Ed. M. Mattson. Elsevier. Volume 16. 2004: 35-56.

      B. Chakravarti and D.N. Chakravarti. "Onchocerciasis." Encyclopedia of Immunology, Eds. I.M. Roitt and P.J. Delves. Academic Press, San Diego, CA. Second edition. 1998: 1872-1875.

    4. Government Reports or Monographs
    5. Book Reviews:
  7. Other Publications

    1. Books:
    2. Papers in Professional Journals:
      1. Articles:
      2. Proceedings:
        1. Refereed Proceedings
        2. Non-Refereed Proceedings
    3. Chapters in Books:
    4. Government Reports or Monographs
    5. Book Reviews:
  8. Presented Papers, Lectures, And Exhibitions And Performances

  9. Work In Progress

    1. Books in progress:
    2. Papers in Progress:
    3. Papers submitted to journals for consideration:
    4. Research in progress:
  10. Professional Honors, Prizes, Fellowships

    Inaugural President’s Award For Student Research Engagement, Third Research Day: for enhancing student research and for commitment to the college’s deepening and widening of student research pursuits, York College, The City University of New York: 2012.

    Students' Choice Award for Outstanding Teaching, Keck Graduate Institute of Applied Life Sciences, The Claremont Colleges: 2006 and 2008.

    Declared as a Chartered Chemist by the the Institution of Chemists (India): 1999.

    Wyeth Lederle Vaccines (now Pfizer Vaccines) R&D Teamwork Award: The Team Leader of the Protein Characterization Team for FDA approval of the Product License Application for a recombinant conjugate vaccine carrier protein: 1998.

    Elected Fellow of the Institution of Chemists (India): 1986.

    State Scholarship of the Government of West Bengal, India for higher studies and research in the U.K.: 1979 to 1883.

    Commonwealth Scholarship of the Commonwealth Universities Association, U.K.: 1978 (declined).

    National Science Talent Search (NSTS) Scholarship of the National Council for Educational Research and Training, Government of India: 1969 to 1979.

    National Scholarship of the Government of India: 1969 and 1972.

    Jagadish Chandra Bose National Science Talent Search (JBNSTS) Science Fair – First Prize: 1969.

  11. Grants-In-Aid

  12. Institutional Service

    1. Service to the Department
    2. Service to the School
    3. Service to the College
    4. Service to the Graduate Center
    5. Service to the University
  13. Offices Held In Professional Societies

  14. Other Professional Activities And Public Service

  15. Teaching Activities At This Institution

    1. Courses Taught (List)
    2. New courses/programs developed (list):
Chakravarti, Deb
 

Chakravarti, Deb
Professor
Chemistry