VSV Vectored HIV Vaccine Odyssey: From Lab to Clinic

Viruses such as HIV-1 replicate within cells. Immune recognition of an intra-cellular infection results in a response characterized by both antibody immunity capable of blocking virus entry into cells and Cell-Mediated Immunity capable of killing virus infected cells.

This lecture will trace the 10-year development pathway of an HIV-1 vaccine based on a recombinant Vesicular Stomatitis Virus vector, the first replication competent recombinant virus vaccine to enter the clinic.

Topics to be discussed will include theresearch, development, and regulatory challenges in the development of this vaccine candidate.