Desamero, Ruel
- Overview
MARC Director
Assistant Professor
Chemistry
Phone: 718-262-2657
Office Location: AC-3F01
desamero@york.cuny.edu
| Office Hours | |
|---|---|
| Tuesday | 10-11 |
| Thursday | 9-11 |
- Education:
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Degree Institution Field Dates PhD University of Connecticut Chemistry 1998
Dr. Desamero joined the York College faculty in 2003. His research is centered on investigating protein-small molecule (substrate, cofactor, and/or inhibitors) interactions using spectroscopic techniques. One goal of the work is to understand how enzymes work at the molecular level. He hopes to address the mechanism of binding and catalysis in enzymes. Currently he is working with dihydropteridine reductase (DHPR). This enzyme is important in the normal cycling of tetrahydrobiopterin, a cofactor in the synthesis of precursors of serotonin and cathecholamine. DHPR deficiency leads to hyperphenylalanine anemia or atypical phenylketonuria.
- Areas of Expertise:
- Protein Biochemistry
Vibrational Spectroscopy
Time-resolved studies
- Articles in Field Of Expertise:
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1. Frank, H.A., V. Chynwat, R.Z.B. Desamero, R. Farhoosh, J.P. Erickson and J. Bautista. "On the Photochemical Properties of Carotenoids and their Role as Light-Harvesting Pigments in Photosynthesis." Pure Appl. Chem. 69 1997: 2117-2124.
2. Frank, H.A., R.Z.B. Desamero, V. Chynwat, R. Gebhard, I. van der Hoef, F.J. Jansen, J. Lugtenburg, D. Gosztola and M.R. Wasielewski. "The Spectroscopic Properties of Spheroidene Analogs having Different Extents of -Electron Conjugation." J. Phys. Chem. 101 1997: 149-157.
3. Desamero, R.Z.B., V. Chynwat, R. Gebhard, I. van der Hoef, F.J. Jansen, J. Lugtenburg, D. Gosztola, M.R. Wasielewski, Agnes Cua, David F. Bocian and H.A. Frank. "The Mechanism of Energy Transfer from Carotenoids to Bacteriochlorophyll: Light-Harvesting by Carotenoids having Different Extents of -Electron Conjugation Incorporated into the B850 Antenna Complex from carotenoidless bacterium Rhodobacter sphaeroides R-26.1." J. Phys. Chem. B. 102 1998: 8151-8162.
4. Kong, J., Z. Lu, R.Z.B. Desamero, H.A. Frank and J.F. Rusling. "Direct Electrochemistry of Cofactor Redox Sites in a Bacterial Photosynthetic Reaction Center Protein." J. Am. Chem. Soc. 120 1998: 7371-7372.
5. Kong, J., W. Sun, X. Wu, J. Deng, Z. Lu, Y. Lvov, R.Z.B. Desamero, H.A. Frank and J. F. Rusling. "Fast Reversible Electron Transfer for Photosynthetic Reaction Center from Wild Type Rhodobacter sphaeroides re-constituted in polycation sandwiched monolayer film." Bioelectrochemistry and Bioenergetics. 48 1999: 101-107.
6. Desamero, R.Z.B., H. Cheng, S. Cahill, M. Girvin, H. Deng, R. Callender, P. Rath, B. Variano and J. Smart. "Interaction of Amidated Acids with Heparin." Biopolymers. 67 2002: 41-48.
7. Desamero, R.Z.B., H. Cheng, S. Cahill, M. Girvin, H. Deng, R. Callender, P. Rath, B. Variano and J. Smart. "The Physical Properties of Compounds that Promote the Oral Delivery of Macromolecular Drugs." Biopolymers. 67 2002: 26-40.
8. Desamero, R.Z.B., S. Rozovsky, N. Zhadin, A. McDermott and R. Callender. "Active Site Loop Motion in Triosephosphate Isomerase: T-jump relaxation spectroscopy of thermal activation." Biochemistry. 40 2003: 3767-3773.
9. Gulotta, M., L. Qui, R. Desamero, J. Rosgen, D.W. Bolen, and R. Callender. "Effects of Cell Volume Regulating Osmolytes on Glycerol 3-Phosphate Binding to Triosephosphate Isomerase." Biochemistry. 46 2007: 10055-10062.
10. Kang, J. and R.Z.B. Desamero. "Synthesis of 6-amino-2,3-dimethylpyrimido[4,5-e][1,2,4] triazine-8-one as an inhibitor of dihydropteridine reductase (DHPR)." Letters in Organic Chemistry. 5 2008: 87-91.
11. Juszczak, L.J. and R.Z.B. Desamero. "Extension of tryptophan dihedral angle-W3 band frequency relationship to a full rotation: correlations and caveats." Biochemistry. 48 2009: 2777-2787.
12. Desamero, R.Z.B., J. Kang, C. Dol, J. Chinwong, K. Walters, T. Sivirajah, and A.A. Profit. "Spectroscopic Characterization of the SH2- and Active Site-Directed Peptide Sequences of a Bivalent Src Kinase Inhibitor." Applied Spectroscopy. 63 2009: 767-774.
