Levinger L, O Jacobs*, M James*. 2001. In vitro 3' end endonucleolytic processing defect in a human mitochondrial tRNASer(UCN) precursor with the U7445C substitution, which causes non-syndromic deafness. Nucleic Acids Res. 29:4334-4340.
In this paper (published in Nucleic Acids Research), we demonstrated that the defect in a mutant mitochondrially encoded pre-tRNA associated with non-syndromic deafness is in the 3' end processing by tRNase Z. Student co-authors (Obasanjo Jacobs and Melissa James) continued in their professional education (DO School and PhD in Cell and Molecular Biology) after receiving research laboratory training with Dr. Levinger
Levinger NAR '01.pdf — PDF document, 448 KB (459323 bytes)