Louis Levinger
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Levinger
L, O Jacobs*, M James*. 2001. In vitro 3' end endonucleolytic
processing defect in a human mitochondrial tRNASer(UCN) precursor with
the U7445C substitution, which causes non-syndromic deafness. Nucleic
Acids Res. 29:4334-4340.
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by
Louis Levinger
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last modified
Feb 21, 2008 09:04PM
- In this paper (published in Nucleic Acids Research), we demonstrated that the defect in a mutant mitochondrially encoded pre-tRNA associated with non-syndromic deafness is in the 3' end processing by tRNase Z. Student co-authors (Obasanjo Jacobs and Melissa James) continued in their professional education (DO School and PhD in Cell and Molecular Biology) after receiving research laboratory training with Dr. Levinger
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Levinger,
L., Giegé, R., Florentz, C. 2003. Pathology-related substitutions in
human mitochondrial tRNAIle reduce precursor 3' end processing
efficiency in vitro. Nucleic Acids Res. 31:1904-1912.
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by
Louis Levinger
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last modified
Feb 21, 2008 09:04PM
- This publication in Nucleic Acids Research is the first of a series based on Dr. Levinger's sabbatical with Catherine Florentz and Richard Giege at the Institute for Cellular and Molecular Biology in Strasbourg, France from 2001-2002. The general topic of the sabbatical research was precursor tRNA 3' end processing and mitochondrially transmitted human diseases. The research was supported by a fellowship from the NIH.
